C₁₈H₁₉FN₂O₄

Base Information

• Chemical Name: C₁₈H₁₉FN₂O₄
• CAS No.: 1369768-06-8
• Molecular Formula: C₁₈H₁₉FN₂O₄
• Molecular Weight: 346.358
• Mol file: 1369768-06-8.mol

Synonyms:

Chemical Property of C₁₈H₁₉FN₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₉FN₂O₄

There total 5 articles about C₁₈H₁₉FN₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H21FN2O3 → C18H19FN2O4 (1369768-06-8)

Guidance literature:

C₁₈H₂₁FN₂O₃; With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -60 - 20 ℃; for 1h;

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; acetone; at 20 ℃; for 14h;

DOI:10.1021/jm400772t

Reference yield:

(1S,5R)-2-oxo-1-(3-fluorophenyl)-3-oxabicyclo[3.1.0]hexane (528587-70-4) → C18H19FN2O4 (1369768-06-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 - 20 °C

2.1: lipase acrylic resin from Candida antarctica / 17 h / 20 °C / Enzymatic reaction

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / 15 h / 0 - 20 °C

3.2: 1 h / 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 1 h / -60 - 20 °C

4.2: 14 h / 20 °C

With sodium tetrahydroborate; oxalyl dichloride; di-isopropyl azodicarboxylate; lipase acrylic resin from Candida antarctica; dimethyl sulfoxide; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 3.1: |Mitsunobu Displacement / 4.1: |Swern Oxidation;

DOI:10.1021/jm400772t

Reference yield:

((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol (1369767-20-3) → C18H19FN2O4 (1369768-06-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lipase acrylic resin from Candida antarctica / 17 h / 20 °C / Enzymatic reaction

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / 15 h / 0 - 20 °C

2.2: 1 h / 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 1 h / -60 - 20 °C

3.2: 14 h / 20 °C

With oxalyl dichloride; di-isopropyl azodicarboxylate; lipase acrylic resin from Candida antarctica; dimethyl sulfoxide; triethylamine; triphenylphosphine; In dichloromethane; 2.1: |Mitsunobu Displacement / 3.1: |Swern Oxidation;

DOI:10.1021/jm400772t

upstream raw materials:

(1S,5R)-2-oxo-1-(3-fluorophenyl)-3-oxabicyclo[3.1.0]hexane

((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol

[(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate

3-fluorophenylacetonitrile

Downstream raw materials:

C₁₈H₂₀FN₃O₃

(1R,2S)-2-(((2-methyl-4-methoxymethylpyrimidin-5-yl)oxy)methyl)-N-(5-fluoropyridin-2-yl)-2-(3-fluorophenyl)cyclopropanecarboxamide

Refernces