Cyclopentylhydrazine dihydrochloride

Base Information

• Chemical Name: Cyclopentylhydrazine dihydrochloride
• CAS No.: 645372-27-6
• Molecular Formula: C5H14Cl2N2
• Molecular Weight: 173.08
• Hs Code.: 2928000090
• European Community (EC) Number: 823-902-3
• DSSTox Substance ID: DTXSID70592987
• Mol file: 645372-27-6.mol

Synonyms:645372-27-6;cyclopentylhydrazine dihydrochloride;Cyclopentyl hydrazine dihydrochloride;1-cyclopentylhydrazine dihydrochloride;CYCLOPENTYL-HYDRAZINE DIHYDROCHLORIDE;cyclopentylhydrazine;dihydrochloride;1-CYCLOPENTYLHYDRAZINE 2HCL;CYCLOPENTYLHYDRAZINEDIHYDROCHLORIDE;TYCOR(TM);SCHEMBL1742157;DTXSID70592987;FPQRIFDTYLBNHV-UHFFFAOYSA-N;cyclopentylhydrazine dihydrochioride;MFCD06800488;AKOS005146478;AB92209;CS-W000556;AM803574;BL010355;KS-10420;EN300-34985;A26941;Cyclopentylhydrazinato--hydrogen chlorido (1/2);J-803015;Z285139110

Chemical Property of Cyclopentylhydrazine dihydrochloride

Chemical Property:

• Vapor Pressure: 0.00615mmHg at 25°C
• Boiling Point: 268 °C at 760 mmHg
• Flash Point: 115.9 °C
• PSA: 38.05000
• LogP: 3.08750
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 172.0534038
• Heavy Atom Count: 9
• Complexity: 48

Purity/Quality:

98%,99%, ^*data from raw suppliers

CyclopentylhydrazineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C1)NN.Cl.Cl

Technology Process of Cyclopentylhydrazine dihydrochloride

There total 8 articles about Cyclopentylhydrazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 2-cyclopentylidenehydrazine carboxylate (79201-39-1) → cyclopentylhydrazine hydrochloride (24214-72-0,645372-27-6)

Guidance literature:

tert-butyl 2-cyclopentylidenehydrazine carboxylate; With sodium cyanoborohydride; In tetrahydrofuran; methanol; for 0.166667h; Heating / reflux;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃; for 4.5h; Heating / reflux;

Reference yield:

Nα,Nβ-bis(tert-butyloxycarbonyl)-Nα-(cyclopentyl)hydrazine → cyclopentylhydrazine hydrochloride (24214-72-0,645372-27-6)

Guidance literature:

N^α,N^β-bis(tert-butyloxycarbonyl)-N^α-(cyclopentyl)hydrazine; With acetyl chloride; In methanol; at 0 ℃; Sealed tube;

With hydrogenchloride; In methanol; at 20 ℃; Sealed tube;

DOI:10.1039/C9CC00492K

Reference yield:

tert-butyl 2-cyclopentylhydrazinecarboxylate (646071-31-0) → cyclopentylhydrazine hydrochloride (24214-72-0,645372-27-6)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 0.166667h; Yield given; Heating;

DOI:10.1021/jo00339a035

upstream raw materials:

tert-butyl 2-cyclopentylhydrazinecarboxylate

tert-butyl 1-cyclopentylhydrazinecarboxylate

tert-butyl 2-cyclopentylidenehydrazine carboxylate

cyclopentanone

Downstream raw materials:

6-Methoxy-1,2,3,4-tetrahydrocyclopentaindole

C₂₁H₂₄N₂O

Refernces

• 1、 -. "PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS PDE9 INHIBITORS". Page/Page column 18; 19. . Retrieved 2014/02/16.
• 2、 Krishnamurthy, Mathangi,Li, Wei,Moore II, Bob M.. "Synthesis, biological evaluation, and structural studies on N1 and C5 substituted cycloalkyl analogues of the pyrazole class of CB1 and CB2 ligands". . p. 393 - 404. Retrieved 2007/10/03.