Technology Process of N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-dimethyl ester
There total 10 articles about N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-dimethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
Inert atmosphere;
L-glutamic dimethyl ester hydrochloride;
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
- Guidance literature:
-
C15H14N4O3;
With
1,1'-carbonyldiimidazole;
In
N,N-dimethyl-formamide;
L-glutamic dimethyl ester hydrochloride;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: hydrogen / palladium on carbon
2: sodium tetrahydroborate
3: triethylamine / tetrahydrofuran
4: hydrogenchloride; acetic acid
5: sodium hydroxide / acetonitrile; water
6: sodium hydroxide; water
7: hydrogenchloride / water
8: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide
With
hydrogenchloride; sodium tetrahydroborate; water; hydrogen; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide;
palladium on carbon;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
