(R)-2-(Methoxydiphenylmethyl)pyrrolidine

Base Information

• Chemical Name: (R)-2-(Methoxydiphenylmethyl)pyrrolidine
• CAS No.: 948595-05-9
• Molecular Formula: C18H21NO
• Molecular Weight: 267.36
• Hs Code.: 2933990090
• European Community (EC) Number: 635-635-8
• DSSTox Substance ID: DTXSID70584827
• Nikkaji Number: J989.448I
• Wikidata: Q72489764
• Mol file: 948595-05-9.mol

Synonyms:(R)-2-(Methoxydiphenylmethyl)pyrrolidine;948595-05-9;(R)-2-(METHOXYDIPHENYLMETHYL) PYRROLIDINE;(2R)-2-[Methoxy(diphenyl)methyl]pyrrolidine;(2R)-2-(METHOXYDIPHENYLMETHYL)PYRROLIDINE;SCHEMBL10326847;DTXSID70584827;CGUGCZSRPDCLBT-QGZVFWFLSA-N;AMY25977;AKOS015908830;(R)-2-(Methoxydiphenylmethyl)pyrrolidine, 95% (HPLC)

Chemical Property of (R)-2-(Methoxydiphenylmethyl)pyrrolidine

Chemical Property:

• Vapor Pressure: 1.25E-05mmHg at 25°C
• Refractive Index: 1.564
• Boiling Point: 368.7 °C at 760 mmHg
• Flash Point: 157.8 °C
• PSA: 21.26000
• Density: 1.07 g/cm³
• LogP: 3.65740
• Storage Temp.: 2-8°C
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 267.162314293
• Heavy Atom Count: 20
• Complexity: 274

Purity/Quality:

98%min ^*data from raw suppliers

(R)-2-(Methoxydiphenylmethyl)pyrrolidine 95% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC(C1CCCN1)(C2=CC=CC=C2)C3=CC=CC=C3
• Isomeric SMILES: COC([C@H]1CCCN1)(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of (R)-2-(Methoxydiphenylmethyl)pyrrolidine

There total 2 articles about (R)-2-(Methoxydiphenylmethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R)-1-tert-butyl-(λ1-oxidanyl)-(λ3-sulfanyl)-2-(methoxydiphenylmethyl)pyrrolidine → (R)-2-(methoxydiphenylmethyl)pyrrolidine (948595-05-9)

Guidance literature:

(R)-1-tert-butyl-(λ¹-oxidanyl)-(λ³-sulfanyl)-2-(methoxydiphenylmethyl)pyrrolidine; With hydrogenchloride; In methanol; at 0 - 70 ℃; for 4h;

With sodium hydrogencarbonate; In tetrahydrofuran; methanol; at 20 ℃; for 6h;

DOI:10.1021/acs.joc.8b01381

Reference yield:

benzhydryl methyl ether (1016-09-7) → (R)-2-(methoxydiphenylmethyl)pyrrolidine (948595-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -40 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: hydrogenchloride / methanol / 4 h / 0 - 70 °C

2.2: 6 h / 20 °C

With hydrogenchloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; methanol; hexane;

DOI:10.1021/acs.joc.8b01381

Reference yield: 85.0%

(R)-2-(methoxydiphenylmethyl)pyrrolidine (948595-05-9) + isovaleraldehyde (590-86-3) → C23H29NO

Guidance literature:

In dimethylsulfoxide-d6;

DOI:10.1002/chem.201905614

upstream raw materials:

benzhydryl methyl ether

Refernces