(S)-1-Boc-3-(Cbz-amino)-piperidine

Base Information

• Chemical Name: (S)-1-Boc-3-(Cbz-amino)-piperidine
• CAS No.: 1002360-09-9
• Molecular Formula: C₁₈H₂₆N₂O₄
• Molecular Weight: 334.415
• Hs Code.: 29333990
• Mol file: 1002360-09-9.mol

Synonyms:(S)-1-Boc-3-(Cbz-amino)-piperidine;

Chemical Property of (S)-1-Boc-3-(Cbz-amino)-piperidine

Chemical Property:

• Boiling Point: 471.6 °C at 760 mmHg
• PKA: 12.05±0.20(Predicted)
• Flash Point: 239 °C
• PSA: 67.87000
• Density: 1.15 g/cm³
• LogP: 3.64110
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(S)-tert-Butyl3-(benzyloxycarbonylamino)-piperidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-Boc-3-(Cbz-amino)-piperidine

There total 6 articles about (S)-1-Boc-3-(Cbz-amino)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.8%

benzyl chloroformate (501-53-1,94274-21-2) + tert‐butyl 3‐aminopiperidine‐1‐carboxylate (144243-24-3) → 3(R)-Benzyloxycarbonylamino-piperidine-1-carboxylic acid tert-butyl ester (183207-70-7,1002360-09-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2017.03.013

Reference yield: 57.0%

→ tert-butyl (3R)-3-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate (320580-76-5,1002360-09-9)

Guidance literature:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + tert-butyl (3S)-3-aminopiperidine-1-carboxylate (625471-18-3) → tert-butyl (3S)-3-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate (1002360-09-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

upstream raw materials:

diphenylphosphoranyl azide

N-(tert-butyloxycarbonyl)nipecotic acid

benzyl chloroformate

tert‐butyl 3‐aminopiperidine‐1‐carboxylate

Downstream raw materials:

N-(1-tert-butoxycarbonyl-3-piperidyl)acetamide

Refernces

• 1、 -. "INHIBITORS OF CYCLIN DEPENDNT KINASE 7 (CDK7)". Paragraph 819. . Retrieved 2018/02/28.
• 2、 -. "AMIDE DERIVATIVE". Page/Page column 120. . Retrieved 2009/12/05.