6-METHYL-2-PIPERIDINE CARBOXYLIC ACID

Base Information

• Chemical Name: 6-METHYL-2-PIPERIDINE CARBOXYLIC ACID
• CAS No.: 99571-58-1
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.186
• Hs Code.: 2933399090
• Mol file: 99571-58-1.mol

Synonyms:2-piperidinecarboxylic acid, 6-methyl-;

Chemical Property of 6-METHYL-2-PIPERIDINE CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 247 - 249 °C
• Refractive Index: 1.465
• Boiling Point: 266.996 °C at 760 mmHg
• PKA: 2.48±0.40(Predicted)
• Flash Point: 115.276 °C
• PSA: 49.33000
• Density: 1.063 g/cm³
• LogP: 0.93040
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

6-methyl-2-piperidinecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-METHYL-2-PIPERIDINE CARBOXYLIC ACID

There total 5 articles about 6-METHYL-2-PIPERIDINE CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

6-methylpyridine-2-carboxylic acid hydrochlorid salt (87884-49-9) → cis-6-methylpipecolinic acid (89115-89-9,89163-80-4,89460-67-3,99571-58-1)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; water; at 60 ℃; for 24h; under 3102.9 Torr;

DOI:10.1021/jo00289a058

Reference yield:

2-methylpyridine N-oxide (931-19-1) → cis-6-methylpipecolinic acid (89115-89-9,89163-80-4,89460-67-3,99571-58-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylcarbamyl chloride / CH₂Cl₂ / 24 h / Ambient temperature

2: 96 percent / 6 N HCl / 24 h / Heating

3: 87 percent / hydrogen / platinum oxide / ethanol; H₂O / 24 h / 60 °C / 3102.9 Torr

With hydrogenchloride; hydrogen; N,N-Dimethylcarbamoyl chloride; platinum(IV) oxide; In ethanol; dichloromethane; water;

DOI:10.1021/jo00289a058

Reference yield:

2-Cyano-6-methylpyridine (1620-75-3) → cis-6-methylpipecolinic acid (89115-89-9,89163-80-4,89460-67-3,99571-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / 6 N HCl / 24 h / Heating

2: 87 percent / hydrogen / platinum oxide / ethanol; H₂O / 24 h / 60 °C / 3102.9 Torr

With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; water;

DOI:10.1021/jo00289a058

upstream raw materials:

6-methylpyridine-2-carboxylic acid hydrochlorid salt

2-methylpyridine N-oxide

2-Cyano-6-methylpyridine

6-methyl-2-pyridinecarboxylic acid

Downstream raw materials:

n-butyl cis-6-methylpipecolinate

cis-6-methylpipecolinic 2,6-dimethylanilide

Refernces

• 1、 Hu, Lain-Yen,Ryder, Todd R.,Nikam, Sham S.,Millerman, Elizabeth,Szoke, Balazs G.,Rafferty, Michael F.. "Synthesis and biological evaluation of substituted 4-(OBz)phenylalanine derivatives as novel N-type calcium channel blockers". . p. 1121 - 1126. Retrieved 2007/10/03.