1620-75-3 Usage
Description
6-Methylpyridine-2-carbonitrile, also known as 6-Methyl-2-pyridinecarbonitrile, is an organic compound that belongs to the pyridine family. It is a white solid with a molecular formula of C7H6N2. 6-Methylpyridine-2-carbonitrile is characterized by its aromatic structure, which includes a pyridine ring with a methyl group at the 6th position and a nitrile group at the 2nd position. Its chemical properties make it a versatile intermediate in the synthesis of various pharmaceutical compounds and materials.
Uses
Used in Pharmaceutical Industry:
6-Methylpyridine-2-carbonitrile is used as an intermediate in the preparation of selective cyclooxygenase-2 (COX-2) inhibitors. These inhibitors are important in the development of anti-inflammatory and pain-relieving drugs, as they help reduce inflammation and pain without causing the side effects associated with non-selective COX inhibitors.
6-Methylpyridine-2-carbonitrile is also used as an intermediate in the synthesis of calcium antagonists. Calcium antagonists are a class of drugs that block the movement of calcium ions across cell membranes, which can help in the treatment of various cardiovascular diseases, such as hypertension, angina, and arrhythmias.
Used in Chemical Research and Development:
6-Methyl-2-pyridinecarbonitrile was used in the synthesis of zinc complexes bearing N,N′-bidentate entiopure ligands. These complexes have potential applications in various fields, including catalysis, coordination chemistry, and materials science. The development of novel zinc complexes can lead to advancements in these areas and contribute to the creation of new technologies and products.
Synthesis Reference(s)
The Journal of Organic Chemistry, 48, p. 1375, 1983 DOI: 10.1021/jo00156a053
Check Digit Verification of cas no
The CAS Registry Mumber 1620-75-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,2 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1620-75:
(6*1)+(5*6)+(4*2)+(3*0)+(2*7)+(1*5)=63
63 % 10 = 3
So 1620-75-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H6N2/c1-6-3-2-4-7(5-8)9-6/h2-4H,1H3
1620-75-3Relevant articles and documents
Studies on the ammoxidation of N heterocyclic compounds. IV. Vapor phase ammoxidation of lutidine isomers
Okada,Morita,Miwa
, p. 2402 - 2406 (1974)
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Method for preparing aryl primary amide by adopting metal-catalyzed one-pot method
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Paragraph 0033; 0034, (2020/04/06)
The invention discloses a method for synthesizing aryl primary amide by adopting a metal-catalyzed one-pot method. The method comprises the steps of: taking aryl bromidess as raw materials, allowing the aryl bromidess to react with a cyanide source under the action of a palladium catalyst, substituting bromine on an aromatic ring with cyano to obtain cyano aromatic hydrocarbon, directly adding anaqueous solution of alkali into the reaction solution without aftertreatment, and carrying out hydrolysis reaction to obtain aryl primary amide. Compared with the prior art, the method for preparing aryl primary amide from the aryl bromides has the advantages of the short synthesis route, fewer reaction steps, simple operation, mild conditions, the high conversion rate, low toxicity and industrialproduction potential.
Synthesis of nitriles from aldehydes with trimethylphenylammonium tribromide and ammonium acetate
Sayama, Shinsei
, p. 1796 - 1802 (2016/11/06)
Various aromatic and heterocyclic aldehydes were easily converted to respective nitriles with the combination of trimethylphenylammonium tribromide and ammonium acetate in good yields at room temperature.
