1-(2-Bromophenylsulfonyl)piperidine

Base Information

• Chemical Name: 1-(2-Bromophenylsulfonyl)piperidine
• CAS No.: 951883-98-0
• Molecular Formula: C11H14BrNO2S
• Molecular Weight: 304.2
• Hs Code.: 2935009090
• Mol file: 951883-98-0.mol

Synonyms:1-(2-Bromophenylsulfonyl)piperidine

Chemical Property of 1-(2-Bromophenylsulfonyl)piperidine

Chemical Property:

• PSA: 45.76000
• LogP: 3.64240
• Storage Temp.: 2-8°C

Purity/Quality:

≥95% ^*data from raw suppliers

1-(2-Bromophenylsulfonyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Bromophenylsulfonyl)piperidine

There total 2 articles about 1-(2-Bromophenylsulfonyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

piperidine (110-89-4) + o-bromobenzenesulfonyl chloride (2905-25-1) → 1-(2-bromobenzenesulfonyl)piperidine (951883-98-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm2006035

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 1-(2-bromobenzenesulfonyl)piperidine (951883-98-0)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / Schlenk technique; Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

With chlorosulfonic acid; triethylamine; In dichloromethane;

DOI:10.1002/adsc.201300795

Reference yield: 61.0%

1-(2-bromobenzenesulfonyl)piperidine (951883-98-0) → 1-(phenylsulfonyl)-1,2,3,4-tetrahydropyridine

Guidance literature:

With palladium diacetate; potassium pivalate; In N,N-dimethyl acetamide; at 150 ℃; for 16h; Schlenk technique; Inert atmosphere;

DOI:10.1002/adsc.201300795

upstream raw materials:

piperidine

o-bromobenzenesulfonyl chloride

bromobenzene

Downstream raw materials:

3-fluoro-2'-(piperidin-1-ylsulfonyl)biphenyl-4-carbaldehyde

1-(phenylsulfonyl)piperidine

Refernces

• 1、 Verhoest, Patrick R.,Sawant Basak, Aarti,Parikh, Vinod,Hayward, Matthew,Kauffman, Gregory W.,Paradis, Vanessa,McHardy, Stanton F.,McLean, Stafford,Grimwood, Sarah,Schmidt, Anne W.,Vanase-Frawley, Michelle,Freeman, Jodi,Van Deusen, Jeffrey,Cox, Loretta,Wong, Diane,Liras, Spiros. "Design and discovery of a selective small molecule κ opioid antagonist (2-methyl- n -((2′-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl) methyl)propan-1-amine, PF-4455242)". experimental part. p. 5868 - 5877. Retrieved 2011/10/08.