Technology Process of (S,S)-1,4-bis((5-sec-butyl-4-hydroxy-3-formylphenyl)ethynyl)benzene
There total 11 articles about (S,S)-1,4-bis((5-sec-butyl-4-hydroxy-3-formylphenyl)ethynyl)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
In
tetrahydrofuran;
at 50 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/ja110052n
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 14 h / 60 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere
3.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere
4.1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran; acetonitrile / 0.75 h / 20 °C / Inert atmosphere
5.1: 2,2'-azobis(isobutyronitrile) / benzene / 0.5 h / Inert atmosphere
5.2: 3 h / 70 °C / Inert atmosphere
6.1: sodium hydroxide / ethanol; water / 3 h / Inert atmosphere; Reflux
7.1: triethylamine; magnesium chloride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux
8.1: Iodine monochloride / acetic acid / 4 h / Reflux; Inert atmosphere
9.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 12 h / 50 °C / Inert atmosphere
With
1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); iodine; Iodine monochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; magnesium chloride;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; acetonitrile; benzene;
9.1: Sonogashira cross oupling;
DOI:10.1021/ja110052n
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydroxide / ethanol; water / 3 h / Inert atmosphere; Reflux
2: triethylamine; magnesium chloride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux
3: Iodine monochloride / acetic acid / 4 h / Reflux; Inert atmosphere
4: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 12 h / 50 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Iodine monochloride; triethylamine; sodium hydroxide; magnesium chloride;
In
tetrahydrofuran; ethanol; water; acetic acid;
4: Sonogashira cross oupling;
DOI:10.1021/ja110052n