4-Bromo-2-iodopyridine

Base Information

• Chemical Name: 4-Bromo-2-iodopyridine
• CAS No.: 100523-83-9
• Molecular Formula: C5H3BrIN
• Molecular Weight: 283.89
• Mol file: 100523-83-9.mol

Synonyms:Pyridine, 4-bromo-2-iodo-;

Chemical Property of 4-Bromo-2-iodopyridine

Chemical Property:

• Vapor Pressure: 0.00569mmHg at 25°C
• Refractive Index: 1.665
• Boiling Point: 282.6 °C at 760 mmHg
• PKA: 0.34±0.10(Predicted)
• Flash Point: 124.7 °C
• PSA: 12.89000
• Density: 2.347 g/cm³
• LogP: 2.44870
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2-iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2-iodopyridine

There total 3 articles about 4-Bromo-2-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-iodo-pyridin-4-ylamine (88511-26-6) → 4-bromo-2-iodopyridine (100523-83-9)

Guidance literature:

With sulfuric acid; copper(II) sulfate; potassium bromide; sodium nitrite; Diazotization_.Reagens 4: Kupfer-Pulver; Reagens 5: Wasser;

Reference yield:

2-iodopyridine (5029-67-4) → 4-bromo-2-iodopyridine (100523-83-9)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; aqueous hydrogen peroxide / Erwaermen des Reaktionsprodukts mit Salpetersaeure und Schwefelsaeure

2: FeSO₄; aqueous NH₃

3: sodium nitrite; aqueous sulfuric acid; copper (II)-sulfate; potassium bromide / Diazotization_.Reagens 4: Kupfer-Pulver; Reagens 5: Wasser

With ammonium hydroxide; sulfuric acid; dihydrogen peroxide; copper(II) sulfate; iron(II) sulfate; acetic acid; potassium bromide; sodium nitrite;

Reference yield:

2-iodo-4-nitropyridine N-oxide (52092-44-1) → 4-bromo-2-iodopyridine (100523-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: FeSO₄; aqueous NH₃

2: sodium nitrite; aqueous sulfuric acid; copper (II)-sulfate; potassium bromide / Diazotization_.Reagens 4: Kupfer-Pulver; Reagens 5: Wasser

With ammonium hydroxide; sulfuric acid; copper(II) sulfate; iron(II) sulfate; potassium bromide; sodium nitrite;

upstream raw materials:

2-iodo-pyridin-4-ylamine

2-iodopyridine

2-iodo-4-nitropyridine N-oxide

Downstream raw materials:

5-bromo-2-phenylpyridine