2,6-Bis(bromomethyl)pyridine

Base Information

• Chemical Name: 2,6-Bis(bromomethyl)pyridine
• CAS No.: 7703-74-4
• Molecular Formula: C7H7Br2N
• Molecular Weight: 264.947
• Hs Code.: 29333990
• Mol file: 7703-74-4.mol

Synonyms:2,6-BIS(BROMOMETHYL)PYRIDINE

Chemical Property of 2,6-Bis(bromomethyl)pyridine

Chemical Property:

• Vapor Pressure: 0.00848mmHg at 25°C
• Melting Point: 85-87 °C(lit.)
• Refractive Index: 1.618
• Boiling Point: 275.6 °C at 760 mmHg
• PKA: 1.65±0.24(Predicted)
• Flash Point: 120.5 °C
• PSA: 12.89000
• Density: 1.87 g/cm³
• LogP: 2.87140
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,6-Bis(bromomethyl)pyridine >99.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2,6-Bis(bromomethyl)pyridine may be used in the preparation of the following:a new pyridine-pyrazole derivative, 2,6-bis(3,5-diphenylpyrazol-1-ylmethyl)pyridinea large macrocyclic ligand, N(1),N(7)-pyridine-2,6-dimethyl-N(2),N(6)-bis(6-(3-(1H-benzo[d]imidazol-1-yl)propanamido)pyridin-2-yl)pyridine-2,6-dicarboxamide dibromidesmall-ring, potentially tridentate Se(2)N(pyridyl)-donor macrocycles

Technology Process of 2,6-Bis(bromomethyl)pyridine

There total 13 articles about 2,6-Bis(bromomethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2.6-bis(hydroxymethyl)pyridine (1195-59-1) → 2,6-bis-(bromomethyl)pyridine (7703-74-4)

Guidance literature:

2.6-bis(hydroxymethyl)pyridine; With hydrogen bromide; In water; at 125 ℃;

With sodium hydrogencarbonate; In water; pH=8;

Reference yield: 95.0%

2,6-dimethylpyridine (108-48-5) + 1,3-dibromo-2-hydroxypropane (96-21-9) → 2,6-bis-(bromomethyl)pyridine (7703-74-4)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 80 ℃; for 24h; Reagent/catalyst;

Reference yield: 93.0%

2,6-dimethylpyridine (108-48-5) → 2,6-bis-(bromomethyl)pyridine (7703-74-4)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; at 75 ℃; for 16h; Inert atmosphere;

upstream raw materials:

2,6-dimethylpyridine

phenyllithium

2.6-bis(hydroxymethyl)pyridine

2,6-bis(methoxycarbonyl)pyridine

Downstream raw materials:

tert-butyl 3,9-bis(2-nitrophenylsulfonyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadecane-1⁽¹⁵⁾,11,13-triene-6-carbamate

tert-butyl 3,9-bis(2-nitrophenylsulfonyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadecane-1⁽¹⁵⁾,11,13-triene-6-acetate

tert-butyl 3,9-bis(2-nitrophenylsulfonyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadecane-1⁽¹⁵⁾,11,13-triene-6-propanoate

2,6-bis((2-(allyloxy)-6-(oct-7-enyloxy)benzyloxy)methyl)pyridine

Refernces

• 1、 Sellmann, Dieter,Ha?u?inger, Daniel,Gottschalk-Gaudig, Torsten,Heinemann, Frank W.. "Transition metal complexes with sulfur ligands, 145 [1]. [Ru(NO)('pybuS4')]br, a complex with [Ru(NO)(NS4)] core, activated CH2 groups, and interionic interactions in the solid state ('pybuS4'2- = 2,6-Bis(2-mercapto-3,5-di-tert-butylphenylthio)dimethylpyridine(2-))". . p. 723 - 729. Retrieved 2000.
• 2、 Dey, Subal,Ahmed, Md Estak,Dey, Abhishek. "Activation of Co(I) State in a Cobalt-Dithiolato Catalyst for Selective and Efficient CO2 Reduction to CO". . p. 5939 - 5947. Retrieved 2018.
• 3、 Pradhan, Rabindra N.,Chakraborty, Subhayan,Bharti, Pratibha,Kumar, Janesh,Ghosh, Arindam,Singh, Akhilesh K.. "Seven coordinate Co(ii) and six coordinate Ni(ii) complexes of an aromatic macrocyclic triamide ligand as paraCEST agents for MRI". . p. 8899 - 8910. Retrieved 2019.
• 4、 Dioury, Fabienne,Ferroud, Clotilde,Guy, Alain,Port, Marc. "Synthesis of an hexadentate tricyclic tetraazadiacetic ligand as precursor for MRI contrast enhancement agents". . p. 7573 - 7579. Retrieved 2009.
• 5、 Newcomb,M. et al.. "-". . p. 6810 - 6811. Retrieved 1974.
• 6、 Ye, Gaoyang,Roques, Jérome,Solari, Pier-Lorenzo,Den Auwer, Christophe,Jeanson, Aurélie,Brandel, Jérémy,Charbonnière, Lo?c J.,Wu, Wangsuo,Simoni, éric. "Structural and Thermodynamics Studies on Polyaminophosphonate Ligands for Uranyl Decorporation". . p. 2149 - 2159. Retrieved 2021/02/16.
• 7、 -. "CHELATORS AND METHODS OF MAKING AND USING SAME". Paragraph 0084; 0102. . Retrieved 2020/10/09.