(R)-2-(4-CHLORO-PHENYL)-3-METHYL-BUTYRIC ACID

Base Information

• Chemical Name: (R)-2-(4-CHLORO-PHENYL)-3-METHYL-BUTYRIC ACID
• CAS No.: 63640-09-5
• Molecular Formula: C11H13ClO2
• Molecular Weight: 212.676
• Hs Code.: 2916399090
• Mol file: 63640-09-5.mol

Synonyms:(2R)-2-(4-Chlorophenyl)-3-methylbutanoic acid;benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-, (alphaR)-

Chemical Property of (R)-2-(4-CHLORO-PHENYL)-3-METHYL-BUTYRIC ACID

Chemical Property:

• Vapor Pressure: 0.000148mmHg at 25°C
• Melting Point: 86 - 87 °C
• Boiling Point: 318.7°C at 760 mmHg
• Flash Point: 146.5°C
• PSA: 37.30000
• Density: 1.184g/cm³
• LogP: 3.16420
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

(R)-2-(4-Chloro-phenyl)-3-methyl-butyricacid 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-(4-CHLORO-PHENYL)-3-METHYL-BUTYRIC ACID

There total 24 articles about (R)-2-(4-CHLORO-PHENYL)-3-METHYL-BUTYRIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-chlorophenylacetic Acid (1878-66-6) + isopropyl chloride (75-29-6) → 2-(4-chlorophenyl)-3-methylbutyric acid (2012-74-0,55291-27-5,55332-38-2,63640-09-5)

Guidance literature:

With potassium hydroxide; In 5,5-dimethyl-1,3-cyclohexadiene; water;

Reference yield: 75.0%

2-(4-Chlorophenyl)-3-methylbutyraldehyde (74408-48-3) → 2-(4-chlorophenyl)-3-methylbutyric acid (2012-74-0,55291-27-5,55332-38-2,63640-09-5)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; In water; at 20 ℃; for 0.166667h;

Reference yield: 70.0%

3-Methyl-2-(4'-chlorophenyl)-butyronitrile (2012-81-9) → 2-(4-chlorophenyl)-3-methylbutyric acid (2012-74-0,55291-27-5,55332-38-2,63640-09-5)

Guidance literature:

With sulfuric acid; In water; acetic acid;

DOI:10.1007/BF00956606

upstream raw materials:

3-Methyl-2-(4'-chlorophenyl)-butyronitrile

(S)-3-(1-hydroxyethyl)pyridine

2-(4-Chlorphenyl)-3-methylbuttersaeureanhydrid

(R)-1-(4-pyridinyl)ethanol

Downstream raw materials:

2-(4-chlorophenyl)-3-methyl-(2SR)-butanoyl chloride

S-isopropyl-4-chlorophenylacetic acid

(R)-4-chloro-α-(1-methylethyl)benzenecaetyl chloride

FENVALERATE

Refernces

• 1、 Colombo, Renata,Ferreira, Tanare C. R.,Yariwake, Janete H.,Lanza, Marcos R. V.. "Screening of by-products of esfenvalerate in aqueous medium using SBSE probe desorption GC-IT-MS technique". . p. 1831 - 1837. Retrieved 2015/09/22.
• 2、 Wang, Yingcai,Jiao, Xianyun,Kayser, Frank,Liu, Jiwen,Wang, Zhongyu,Wanska, Malgorzata,Greenberg, Joanne,Weiszmann, Jennifer,Ge, Hongfei,Tian, Hui,Wong, Simon,Schwandner, Ralf,Lee, Taeweon,Li, Yang. "The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators". scheme or table. p. 493 - 498. Retrieved 2010/04/26.