74408-48-3

Basic information

• Product Name: Benzeneacetaldehyde, 4-chloro-a-(1-methylethyl)-
• CAS NO: 74408-48-3
• Molecular Formula: C11H13ClO
• Molecular Weight: 196.677
• Mol File: 74408-48-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzeneacetaldehyde, 4-chloro-a-(1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetaldehyde, 4-chloro-a-(1-methylethyl)-(74408-48-3)
• EPA Substance Registry System: Benzeneacetaldehyde, 4-chloro-a-(1-methylethyl)-(74408-48-3)

Safety Data

• Hazardous Substances Data: 74408-48-3(Hazardous Substances Data)

Upstream product

• 51631-50-6 2-(4-chlorophenyl)-3-methyl-(2SR)-butanoyl chloride 
• 201230-82-2 carbon monoxide 
• 19366-15-5 4-chloro-β,β-dimethylstyrene 
• 18713-58-1 1-(4-chlorophenyl)-2-methylpropan-1-one 
• 65079-44-9 2-(4-Chlorophenyl)-3-methyl-1-butanol 

Downstream Products

• 2012-74-0 2-(4-chlorophenyl)-3-methylbutyric acid 
• 246233-70-5 (Z)-4-(4-Chloro-phenyl)-2-fluoro-5-methyl-hex-2-enoic acid methyl ester 
• 246233-80-7 (Z)-4-(4-Chloro-phenyl)-2-fluoro-5-methyl-hex-2-en-1-ol 
• 55332-38-2 S-isopropyl-4-chlorophenylacetic acid 
• 306974-39-0 (S)-3-methyl-2-(4-chlorophenyl)butan-1-ol 

Relevant articles and documents

Ru-catalyzed asymmetric hydrogenation of racemic aldehydes via dynamic kinetic resolution: Efficient synthesis of optically active primary alcohols

A highly efficient asymmetric hydrogenation of racemic α-arylaldehydes via dynamic kinetic resolution has been developed by using [RuCl2(SDPs)(diamine)] complexes as catalysts, providing chiral primary alcohols in excellent enantioselectivities. Copyright

Studies on the synthesis of chiral 2-(p.chlorophenyl)-3-methylbutanoic acid, a key-precursor of Fenvalerate, by hydrocarbonylation reactions

The preparation of racemic 2-(p.chlorophenyl)-3-methylbutanoic acid (2), a building block for (S,S)-Fenvalerate (an important broad spectrum insecticide), was effected by rhodium catalyzed hydroformylation of 2-methyl-1 -(p.chlorophenyl) propene (4) in the presence of excess of triphenylphosphine to inhibit substrate isomerization followed by mild oxidation of the resulting aldehyde 6; an overall yield of 88% was reached. Olefin 4 exhibits a very low tendency to undergo both hydrocarboethoxylation and hydrocarboxylation in the presence of palladium complexes as catalysts. Enantioselective hydrocarbonylation reactions carried out on olefin 4 afford unsatisfactory chemical and optical yields of the optically active ester 5 or acid 2. Springer-Verlag 1996.

Metal-assisted Reactions. Part 8. Selectivity in the Reaction of Organic Halides with Tetrahydroborate and the Reduction of Acyl Halides to Aldehydes

Addition of metal ions such as Cu+, Cu2+, Cd2+, and Zn2+ with dimethylformamide to sodium tetrahydroborate in acetonitrile affords a reducing medium in which acyl halides are converted to aldehydes but alkyl, aryl, and benzylic halides are unaffected.The inertness of these last, synthetically useful, functional groups along with the inertness of other potentially reducible groups, makes the reagent very selective for direct reduction of acyl halides to aldehydes.The reducing solution is stable, readily prepared from cheap materials, rapid in action, and easy to use, making the conversion of acids to aldehydes via acyl halides a routine synthetic procedure.