18713-58-1

Basic information

• Product Name: 4'-CHLORO-2-METHYLPROPIOPHENONE
• Synonyms: p-chloroisobutyrophenone;p-chlorophenylisopropylketone;4'-CHLORO-2-METHYLPROPIOPHENONE;PROPIOPHENONE,4-CHLORO-2-METHYL;1-(4-chlorophenyl)-2-Methylpropan-1-one;1-(4-chlorophenyl)-2-methyl-1-propanon;1-(4-chlorophenyl)-2-methyl-1-propanone;4’-chloroisobutyrophenone
• CAS NO: 18713-58-1
• Molecular Formula: C₁₀H₁₁ClO
• Molecular Weight: 182.65
• Mol File: 18713-58-1.mol
• Article Data: 38

Chemical Properties

• Boiling Point: 260.78°C (rough estimate)
• Flash Point: 137°C
• Appearance: /
• Density: 1.0929 (rough estimate)
• Refractive Index: 1.5390 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4'-CHLORO-2-METHYLPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-CHLORO-2-METHYLPROPIOPHENONE(18713-58-1)
• EPA Substance Registry System: 4'-CHLORO-2-METHYLPROPIOPHENONE(18713-58-1)

Safety Data

• Hazardous Substances Data: 18713-58-1(Hazardous Substances Data)

Usage

General Description

4'-Chloro-2-methylpropiophenone is a chemical usually found in various industrial and laboratory uses. It belongs to the class of compounds known as phenones which are organic compounds containing a phenyl group bonded to a ketone. Produced synthetically, it is a precursor to many other chemical products and is commonly involved in perfumery, aromas and pharmaceutical industry. 4'-CHLORO-2-METHYLPROPIOPHENONE may appear as a colorless or pale yellow liquid. It is vital to note that it may cause burn and eye irritation, hence protective precautions are needed during its handling.

Upstream product

• 6285-05-8 4'-chloropropiophenone 
• 79-30-1 isobutyryl chloride 
• 108-90-7 chlorobenzene 
• 74-98-6 propane 
• 201230-82-2 carbon monoxide 
• 10557-71-8 4-chlorophenyltrimethylsilane 
• 4405-42-9 m-chlorophenyltrimethylsilane 
• 95-16-9 1,3-Benzothiazole 
• 1300105-82-1 α-methylthio-p-chloroisobutyrophenone 
• 67-56-1 methanol 
• 99-91-2 para-chloroacetophenone 
• 33000-64-5 2-bromo-1-(4-chlorophenyl)-2-methylpropan-1-one 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 78-84-2 isobutyraldehyde 

Downstream Products

• 107153-95-7 1-(4-chlorophenyl)-2-methyl-1-(2-pyridyl)-1-propanol 
• 92026-27-2 5-(4-chloro-phenyl)-4,4-dimethyl-5-oxo-valeronitrile 
• 28115-07-3 3-methyl-2-(p-chlorophenyl)-1-butene 
• 126275-08-9 (E)-3-(4-Chloro-phenyl)-4-methyl-pent-2-enoic acid ethyl ester 
• 88283-73-2 4-chlorophenyl 4-chlorophenyl-tert.-butyl ketone 
• 71867-96-4 1-(4-chlorophenyl)-2-hydroxy-2-methylpropan-1-one 
• 88283-69-6 2-(4-chlorophenyl)-2-[2-(p-chlorophenoxy)-prop-2-yl]-oxirane 
• 55283-69-7 isopyrimol 
• 100710-04-1 1-(4-chloro-phenyl)-2,2-dimethyl-hexane-1,3,5-trione 
• 66185-91-9 1-(4-chloro-phenyl)-2,2-dimethyl-butane-1,3-dione 
• 33000-64-5 2-bromo-1-(4-chlorophenyl)-2-methylpropan-1-one 
• 61658-88-6 4-chloro-1-(2-methylpropyl)benzene 
• 10403-41-5 5-(4-chloro-phenyl)-4-methyl-[1,2]dithiol-3-thione 

Relevant articles and documents

PINACOL REARRANGEMENT OF PHENAGLYCODOL. I. CHARACTERIZATION OF PRODUCTS

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Competitive Desulfonylative Reduction and Oxidation of α-Sulfonylketones Promoted by Photoinduced Electron Transfer with 2-Hydroxyaryl-1,3-dimethylbenzimidazolines under Air

Desulfonylation reactions of α-sulfonylketones promoted by photoinduced electron transfer with 2-hydroxyarylbenzimidazolines (BIH-ArOH) were investigated. Under aerobic conditions, photoexcited 2-hydroxynaphthylbenzimidazoline (BIH-NapOH) promotes competitive reduction (forming alkylketones) and oxidation (producing α-hydroxyketones) of sulfonylketones through pathways involving the intermediacy of α-ketoalkyl radicals. The results of an examination of the effects of solvents, radical trapping reagents, substituents of sulfonylketones, and a variety of hydroxyaryl- and aryl-benzimidazolines (BIH-ArOH and BIH-Ar) suggest that the oxidation products are produced by dissociation of α-ketoalkyl radicals from the initially formed solvent-caged radical ion pairs followed by reaction with molecular oxygen. In addition, the observations indicate that the reduction products are generated by proton or hydrogen atom transfer in solvent-caged radical ion pairs derived from benzimidazolines and sulfonylketones. The results also suggest that arylsulfinate anions arising by carbon-sulfur bond cleavage of sulfonylketone radical anions act as reductants in the oxidation pathway to convert initially formed α-hydroperoxyketones to α-hydroxyketones. Finally, density functional theory calculations were performed to explore the structures and properties of radical ions of sulfonylketones as well as BIH-NapOH.

Method for preparing aryl ketone based on iron-catalyzed free radical-free radical coupling reaction such as ketonic acid decarboxylation and fatty aldehyde de-carbonylation

The invention discloses a method for preparing an aryl ketone derivative based on a free radical-free radical cross-coupling reaction such as ketonic acid decarboxylation and fatty aldehyde de-carbonylation. The method comprises the following steps: reacting aryl-substituted ketonic acid with fatty aldehyde under the catalytic action of ferric triacetylacetonate to generate an aryl ketone derivative; the gram-grade reaction can be realized by the method only by using 3mol% of an iron catalyst; and the method has the advantages of no need of consumption of a large amount of a Lewis acid catalyst or a stoichiometric organic metal reagent, mild reaction conditions, one-step reaction, few by-products, wide substrate application range and scalable reaction, and overcomes the defects of large catalyst consumption, insufficient functional group tolerance, many by-products and the like in the prior art.