4405-42-9 Usage
Functional groups
Chloro-substituted aromatic compound, trimethylsilyl group
Structure
Benzene ring with a chlorine atom at the 3-position and a trimethylsilyl group at the 1-position
Applications
Organic synthesis, pharmaceutical and agricultural industries, specialty chemicals and materials
Reactivity
Can undergo cross-coupling and halogenation reactions
Protective group
Trimethylsilyl group allows for selective reactions at other functional groups
Versatility
Presence of both chloro and trimethylsilyl groups makes the compound useful for synthetic chemistry
Check Digit Verification of cas no
The CAS Registry Mumber 4405-42-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,0 and 5 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4405-42:
(6*4)+(5*4)+(4*0)+(3*5)+(2*4)+(1*2)=69
69 % 10 = 9
So 4405-42-9 is a valid CAS Registry Number.
4405-42-9Relevant articles and documents
Halogen/lithium exchange in hydrocarbon media; Basic and continuous reactor studies
Slocum,Kusmic, Damir,Raber, Jeffrey C.,Reinscheld, Thomas K.,Whitley, Paul E.
body text, p. 4793 - 4796 (2010/10/02)
The halogen/lithium (X/Li) exchange's usefulness is challenged by the extreme conditions employed during the conversion of a bromo or an iodo substituent to an organolithium intermediate. Our preliminary disclosure reveals that simple X/Li exchanges can be accomplished at ambient temperature and in doped hydrocarbon media using n-BuLi. Use of a continuous reactor featuring brief reaction times (≤1 s) and large product throughputs further facilitates the production of a product resulting from a sequential X/Li exchange and nucleophilic addition.
