(R)-1-Cbz-3-aminopiperidine

Base Information Edit

Chemical Name:(R)-1-Cbz-3-aminopiperidine
CAS No.:1044560-96-4
Molecular Formula:C13H18N2O2
Molecular Weight:234.298
Hs Code.:29339900
DSSTox Substance ID:DTXSID10363799
Wikidata:Q72440647
Mol file:1044560-96-4.mol

Synonyms:1044560-96-4;(R)-1-Cbz-3-aminopiperidine;(r)-benzyl 3-aminopiperidine-1-carboxylate;(R)-3-Amino-1-N-Cbz-piperidine;benzyl (3R)-3-aminopiperidine-1-carboxylate;(r)-3-amino-1-cbz-piperidine;MFCD05864625;SCHEMBL764193;(R)-3-Amino-piperidine-1-carboxylic acid benzyl ester;(r)-n-cbz-3-amino-piperidine;AMY4236;DTXSID10363799;(R)-1-CBZ-3-Aminopiperidine-HCl;AKOS015836861;AKOS015897831;CS-W003252;DS-1540;AC-29151;(r)-benzyl3-aminopiperidine-1-carboxylate;(r)-benzyl-3-aminopiperidine-1-carboxylate;Q-102971;(R)-benzyl 3-aminopiperidine-1-carboxylate

Suppliers and Price of (R)-1-Cbz-3-aminopiperidine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 35 raw suppliers

Chemical Property of (R)-1-Cbz-3-aminopiperidine Edit

Chemical Property:

Boiling Point:367.235 °C at 760 mmHg
Flash Point:175.898 °C
PSA：55.56000
Density:1.152 g/cm³
LogP:2.38450
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:234.136827821
Heavy Atom Count:17
Complexity:252

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(CN(C1)C(=O)OCC2=CC=CC=C2)N
Isomeric SMILES:C1C[C@H](CN(C1)C(=O)OCC2=CC=CC=C2)N

Technology Process of (R)-1-Cbz-3-aminopiperidine

There total 5 articles about (R)-1-Cbz-3-aminopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 485820-12-0
(R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester

: 1044560-96-4
(R)-benzyl 3-aminopiperidine-1-carboxylate

Guidance literature:: (R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In water; Saturated solution;

Reference yield:

: 1050446-94-0
C₁₄H₁₈N₂O₃

: 1044560-96-4
(R)-benzyl 3-aminopiperidine-1-carboxylate

Guidance literature:: With sodium hypochlorite; sodium hydroxide; In water; at 25 - 40 ℃;

Reference yield:

: 160706-62-7
(R)-1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid

: 1044560-96-4
(R)-benzyl 3-aminopiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: methanesulfonyl chloride; ammonia; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -10 - 25 °C

2: sodium hydroxide; sodium hypochlorite / water / 25 - 40 °C

With sodium hypochlorite; ammonia; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; water; 2: |Hofmann Rearrangement;