Ethyl 2-cyclopropylacetate

Base Information

• Chemical Name: Ethyl 2-cyclopropylacetate
• CAS No.: 53432-87-4
• Molecular Formula: C7H12O2
• Molecular Weight: 128.17
• European Community (EC) Number: 827-426-7
• Mol file: 53432-87-4.mol

Synonyms:ETHYL 2-CYCLOPROPYLACETATE;53432-87-4;ETHYL CYCLOPROPANEACETATE;Ethyl cyclopropaneacetate;MFCD11976041;ethyl cyclopropylacetate;Cyclopropaneacetic acid ethyl ester;Cyclopropaneacetic acid, ethyl ester;SCHEMBL2721040;ETHYL2-CYCLOPROPYLACETATE;AMY4002;AODPICOFZRYWKI-UHFFFAOYSA-N;AKOS009291418;CS-W000547;PB42995;AC-29216;AS-48579;SY191891;FT-0730626;EN300-75032;F51522;A870728;Z380123288

Chemical Property of Ethyl 2-cyclopropylacetate

Chemical Property:

• Boiling Point: 157.8±8.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.006±0.06 g/cm3(Predicted)
• LogP: 1.34960
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 128.083729621
• Heavy Atom Count: 9
• Complexity: 106

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-Cyclopropylacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CC1CC1

Technology Process of Ethyl 2-cyclopropylacetate

There total 10 articles about Ethyl 2-cyclopropylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl cyclopropenylideneacetate (74592-36-2) → ethyl 2-cyclopropyl acetate (53432-87-4)

Guidance literature:

With methanol; sodium tetrahydroborate; CoCl₂((R,R)-NaphdiPIM-dioxo-iPr); In dichloromethane; at 0 - 25 ℃; for 1h; enantioselective reaction; Schlenk technique;

DOI:10.1002/cctc.201500260

Reference yield: 75.0%

ethanol (64-17-5) + cyclopropylacetic acid (5239-82-7) → ethyl 2-cyclopropyl acetate (53432-87-4)

Guidance literature:

With sulfuric acid; Reflux;

DOI:10.1021/jacs.0c07918

Reference yield: 75.0%

ethanol (64-17-5) + 1-cyclopropyl-1,1-diethoxyethane (59226-78-7) → ethyl 2-cyclopropyl acetate (53432-87-4) + 2-bromo-1-cyclopropyl-1,1-diethoxyethane (266683-60-7)

Guidance literature:

1-cyclopropyl-1,1-diethoxyethane; With bromine; In dichloromethane; at 25 - 30 ℃;

ethanol; for 0.05h; Further stages.;

DOI:10.1021/jo9917644

upstream raw materials:

diazomethane

ethanol

cyclopropanecarboxylic acid chloride

diiodomethane

Downstream raw materials:

2-cyclopropylacetaldehyde

2-(cyclopropyl)ethylamine

6-Cyclopropyl-7-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

4-(2'-Cyano-biphenyl-4-ylmethyl)-6-cyclopropyl-7-oxo-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

Refernces

• 1、 Clayman, Phillip D.,Hyster, Todd K.. "Photoenzymatic Generation of Unstabilized Alkyl Radicals: An Asymmetric Reductive Cyclization". supporting information. p. 15673 - 15677. Retrieved 2020/10/18.
• 2、 -. "KINASE INHIBITORS AND USES THEREOF". Paragraph 0256; 0304. . Retrieved 2018/12/13.