2,5-Dimethylterephthalonitrile

Base Information

• Chemical Name: 2,5-Dimethylterephthalonitrile
• CAS No.: 39095-25-5
• Molecular Formula: C10H8N2
• Molecular Weight: 156.187
• Hs Code.: 2926909090
• Mol file: 39095-25-5.mol

Synonyms:1,4-Benzenedicarbonitrile, 2,5-dimethyl-;

Chemical Property of 2,5-Dimethylterephthalonitrile

Chemical Property:

• Melting Point: 212 °C
• Boiling Point: 337.5 °C at 760 mmHg
• Flash Point: 166 °C
• PSA: 47.58000
• Density: 1.09 g/cm³
• LogP: 2.04676
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly, Heated)

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5-Dimethylterephthalonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,5-Dimethylterephthalonitrile is used as a reagent to synthesize amides via acid-catalyzed hydration of nitrile compounds. 2,5-Dimethylterephthalonitrile is also currently being used in rubber compositions.

Technology Process of 2,5-Dimethylterephthalonitrile

There total 10 articles about 2,5-Dimethylterephthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,5-dibromo-p-xylene (1074-24-4) + copper(l) cyanide → 2,5-dimethylbenzene-1,4-dicarbonitrile (39095-25-5)

Guidance literature:

In N,N-dimethyl-formamide; for 24h; Reflux;

DOI:10.1021/ol200146j

Reference yield: 90.0%

potassium cyanide (151-50-8) + 2,5-dimethyl-1,4-bis(trifluoromethylsulfonyl)benzene → 2,5-dimethylbenzene-1,4-dicarbonitrile (39095-25-5)

Guidance literature:

With triphenylphosphine; nickel; zinc; In N,N-dimethyl-formamide; at 60 ℃; for 3h;

DOI:10.1246/cl.1995.1119

Reference yield: 87.4%

copper(I) cyanide + 2,5-dibromo-p-xylene (1074-24-4) → 2,5-dimethylbenzene-1,4-dicarbonitrile (39095-25-5)

Guidance literature:

In N,N-dimethyl-formamide; at 155 ℃; for 48h;

upstream raw materials:

potassium cyanide

2,5-dibromo-p-xylene

copper(I) cyanide

2,5-dimethylhydroquinone

Downstream raw materials:

2,5-diformyl-terephthalic acid

2-(2-{4-[bis(2-chloroethyl)amino]phenyl}vinyl)-5-methylterephthalonitrile

(E)-2-(4-(4-(pyridin-2-ylmethyl)piperazin-1-yl)styryl)-5-methylterephthalonitrile

2-(bromomethyl)-5-methylterephthalonitrile

Refernces

• 1、 Huang, Chibao,Yang, Yuzhu,Li, Youfeng,Lv, Guoling. "A two-photon fluorescent lipid raft probe derived from dicyanostilbene and similar to cholesterol’s structure". . p. 1223 - 1230. Retrieved 2021/08/26.
• 2、 -. "Double-photon fluorescent probe used for temperature detection and derived from carbazole and preparation method of double-photon fluorescent probe". Paragraph 0024. . Retrieved 2018/04/03.