5,7-Difluoro-6-bromoquinoline

Base Information

• Chemical Name: 5,7-Difluoro-6-bromoquinoline
• CAS No.: 1022091-49-1
• Molecular Formula: C9H4BrF2N
• Molecular Weight: 244.038
• Hs Code.: 29334900
• Mol file: 1022091-49-1.mol

Synonyms:6-Bromo-5,7-difluoroquinoline;Quinoline, 6-bromo-5,7-difluoro-;

Chemical Property of 5,7-Difluoro-6-bromoquinoline

Chemical Property:

• Melting Point: 87-92℃
• Boiling Point: 288.182 °C at 760 mmHg
• PKA: 2.05±0.29(Predicted)
• Flash Point: 128.088 °C
• PSA: 12.89000
• Density: 1.726 g/cm³
• LogP: 3.27550
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

6-Bromo-5,7-difluoroquinoline 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,7-Difluoro-6-bromoquinoline

There total 3 articles about 5,7-Difluoro-6-bromoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-bromo-3,5-difluorophenylamine (203302-95-8) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 6-bromo-5,7-difluoroquinoline (1022091-49-1)

Guidance literature:

With sulfuric acid; sodium 3-nitrobenzenesulfonate; In water; at 120 - 130 ℃; for 1.5h;

Reference yield:

3,5-difluoroaniline (372-39-4) → 6-bromo-5,7-difluoroquinoline (1022091-49-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C

2: iron(II) sulfate; sulfuric acid / nitrobenzene / 5 h / Reflux

With N-Bromosuccinimide; sulfuric acid; iron(II) sulfate; In nitrobenzene; N,N-dimethyl-formamide;

Reference yield:

→ 6-bromo-5,7-difluoroquinoline (1022091-49-1)

Guidance literature:

upstream raw materials:

4-bromo-3,5-difluorophenylamine

glycerol

3,5-difluoroaniline

Downstream raw materials:

5,7-difluoroquinoline-6-carbaldehyde

Refernces

• 1、 -. "Quinoline compounds and preparation method thereof, and intermediate, pharmaceutical composition and application of quinoline compounds". Paragraph 0490-0492. . Retrieved 2018/02/04.
• 2、 -. "IMIDAZO [1,2-B] PYRIDAZINE DERIVATIVES FOR THE TREATMENT OF C-MET TYROSINE KINASE MEDIATED DISEASE". Page/Page column 70. . Retrieved 2009/10/21.