6,10-Dioxaspiro[4.5]decane-7,9-dione

Base Information

• Chemical Name: 6,10-Dioxaspiro[4.5]decane-7,9-dione
• CAS No.: 58093-05-3
• Molecular Formula: C8H10O4
• Molecular Weight: 170.165
• Hs Code.: 2932999099
• European Community (EC) Number: 846-941-8
• DSSTox Substance ID: DTXSID90378149
• Nikkaji Number: J3.625.331B
• Wikidata: Q82167662
• Mol file: 58093-05-3.mol

Synonyms:6,10-dioxaspiro[4.5]decane-7,9-dione;58093-05-3;MFCD01617888;6,10-dioxa-spiro[4.5]decane-7,9-dione;2,2-tetramethylene-4,6-dioxo-1,3-dioxane;SCHEMBL5708888;DTXSID90378149;AMY41371;BCP31948;BBL029430;STK256909;AKOS003259118;CS-W007047;DS-11550;SY115453;A8249;FT-0699436;J3.625.331B;A1-24379

Chemical Property of 6,10-Dioxaspiro[4.5]decane-7,9-dione

Chemical Property:

• Vapor Pressure: 4.33E-08mmHg at 25°C
• Refractive Index: 1.503
• Boiling Point: 444.3 °C at 760 mmHg
• Flash Point: 245.6 °C
• PSA: 52.60000
• Density: 1.3 g/cm³
• LogP: 0.74680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 170.05790880
• Heavy Atom Count: 12
• Complexity: 209

Purity/Quality:

98%min ^*data from raw suppliers

6,10-Dioxaspiro[4.5]decane-7,9-dione 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC2(C1)OC(=O)CC(=O)O2

Technology Process of 6,10-Dioxaspiro[4.5]decane-7,9-dione

There total 4 articles about 6,10-Dioxaspiro[4.5]decane-7,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

malonic acid (141-82-2) + cyclopentanone (120-92-3) → 6,10-dioxaspiro<4.5>decane-7,9-dione (58093-05-3)

Guidance literature:

With acetic anhydride; toluene-4-sulfonic acid; at 20 ℃; for 170h;

DOI:10.1023/B:RUJO.0000043715.53702.cf

Reference yield: 56.0%

→ 6,10-dioxaspiro<4.5>decane-7,9-dione (58093-05-3)

Guidance literature:

Reference yield: 38.0%

cycl-isopropylidene malonate (2033-24-1) + cyclopentanone (120-92-3) → 6,10-dioxaspiro<4.5>decane-7,9-dione (58093-05-3)

Guidance literature:

With acetic anhydride; toluene-4-sulfonic acid; at -70 - 20 ℃;

DOI:10.1002/ejoc.201601448

upstream raw materials:

malonic acid

cyclopentanone

sulfuric acid

acetic anhydride

Refernces

• 1、 -. "NUCLIDE LABELLED H-TETRAZINES AND USE THEREOF FOR PET AND SPECT PRETARGETED IMAGING AND RADIONUCLIDE THERAPY". Page/Page column 31. . Retrieved 2021/11/20.
• 2、 Petersen, Ida Nymann,Kristensen, Jesper Langgaard,Herth, Matthias Manfred. "Nucleophilic18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors: Advantages and Disadvantages". supporting information. p. 453 - 458. Retrieved 2017/02/05.