8-bromoquinolin-6-ol

Base Information

• Chemical Name: 8-bromoquinolin-6-ol
• CAS No.: 159925-99-2
• Molecular Formula: C₉H₆BrNO
• Molecular Weight: 224.057
• Mol file: 159925-99-2.mol

Synonyms:

Chemical Property of 8-bromoquinolin-6-ol

Chemical Property:

• Melting Point: 245 °C (decomp)
• Boiling Point: 363.2±22.0 °C(Predicted)
• Density: 1.705±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

8-Bromoquinolin-6-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-bromoquinolin-6-ol

There total 2 articles about 8-bromoquinolin-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8--bromo--6--methoxyquinoline (50488-36-3) → 8-bromoquinolin-6-ol (159925-99-2)

Guidance literature:

With water; hydrogen bromide;

DOI:10.1021/ja01154a108

Reference yield:

6-methoxyquinolin-8-amine (90-52-8) → 8-bromoquinolin-6-ol (159925-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; sodium nitrite; sulfuric acid / Diazotization_.Erwaermen mit einer Loesung von Kupfer(I)-bromid in wss. Salzsaeure

2: water; hydrobromic acid

With sulfuric acid; water; hydrogen bromide; acetic acid; sodium nitrite;

DOI:10.1021/ja01154a108

Reference yield:

8-bromoquinolin-6-ol (159925-99-2) → benzyl 4-(7-(6-(methoxymethoxy)quinolin-8-yl)-2-(3-morpholinopropoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 1 h / 100 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In dichloromethane; toluene; 2: |Buchwald-Hartwig Coupling;

upstream raw materials:

8--bromo--6--methoxyquinoline

6-methoxyquinolin-8-amine