90-52-8 Usage
Description
8-AMINO-6-METHOXYQUINOLINE is a solid organic compound with a quinoline core structure, featuring an amino group at the 8th position and a methoxy group at the 6th position. It possesses unique chemical and biological properties, making it a versatile molecule for various applications.
Uses
Used in Pharmaceutical Industry:
8-AMINO-6-METHOXYQUINOLINE is used as a pharmaceutical intermediate for the synthesis of various drugs and drug candidates. Its unique structure and functional groups allow for the development of new therapeutic agents with potential applications in treating different diseases.
Used in Antitubercular Applications:
8-AMINO-6-METHOXYQUINOLINE is used as an antimycobacterial agent for its potential anti-tuberculosis application. Its oxidizing properties and antimycobacterial messages make it a promising candidate for the development of new treatments against tuberculosis.
Used in Chemical Synthesis:
8-AMINO-6-METHOXYQUINOLINE is used as a key building block in the synthesis of various organic compounds, including dyes, pigments, and other specialty chemicals. Its reactivity and functional groups enable the formation of a wide range of derivatives with diverse applications.
Used in Research and Development:
8-AMINO-6-METHOXYQUINOLINE is used as a research compound for studying its chemical properties, reactivity, and potential applications in various fields. It serves as a valuable tool for chemists and researchers to explore new synthetic routes and develop innovative products.
Purification Methods
Distil it under N2 and at high vacuum, then recrystallise it several times from MeOH (0.4mL/g). It remains colourless for several months when purified in this way [Elderfield & Rubin J Am Chem Soc 75 2963 1953]. The hydrobromide [312693-53-1] M 255.1 has m 238o(dec). [Beilstein 22 III/IV 5934.]
Check Digit Verification of cas no
The CAS Registry Mumber 90-52-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 0 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 90-52:
(4*9)+(3*0)+(2*5)+(1*2)=48
48 % 10 = 8
So 90-52-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H10N2O/c1-13-8-5-7-3-2-4-12-10(7)9(11)6-8/h2-6H,11H2,1H3
90-52-8Relevant articles and documents
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Barber,Wragg
, p. 610,612 (1946)
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8-amino-6-methoxyquinoline—tetrazole hybrids: Impact of linkers on antiplasmodial activity
Dolensky, Johanna,Hochegger, Patrick,Kaiser, Marcel,M?ser, Pascal,Saf, Robert,Seebacher, Werner,Weis, Robert
, (2021/09/20)
A new series of compounds was prepared from 6-methoxyquinolin-8-amine or its N-(2-aminoethyl) analogue via Ugi-azide reaction. Their linkers between the quinoline and the tert-butyltetrazole moieties differ in chain length, basicity and substitution. Compounds were tested for their antiplasmodial activity against Plasmodium falciparum NF54 as well as their cytotoxicity against L-6-cells. The activity and the cytotoxicity were strongly influenced by the linker and its substitution. The most active compounds showed good activity and promising selectivity.
Minimization of Back-Electron Transfer Enables the Elusive sp3 C?H Functionalization of Secondary Anilines
Zhao, Huaibo,Leonori, Daniele
supporting information, p. 7669 - 7674 (2021/03/08)
Anilines are some of the most used class of substrates for application in photoinduced electron transfer. N,N-Dialkyl-derivatives enable radical generation α to the N-atom by oxidation followed by deprotonation. This approach is however elusive to monosubstituted anilines owing to fast back-electron transfer (BET). Here we demonstrate that BET can be minimised by using photoredox catalysis in the presence of an exogenous alkylamine. This approach synergistically aids aniline SET oxidation and then accelerates the following deprotonation. In this way, the generation of α-anilinoalkyl radicals is now possible and these species can be used in a general sense to achieve divergent sp3 C?H functionalization.