59679-84-4Relevant articles and documents
Cobalt-Catalyzed Regioselective Carboamidation of Alkynes with Imides Enabled by Cleavage of C-N and C-C Bonds
Chen, Bing-Zhi,Chen, Qing-An,Hu, Yan-Cheng,Ji, Ding-Wei,Min, Xiang-Ting,Wan, Boshun,Zheng, Hao
supporting information, p. 3386 - 3391 (2020/04/20)
Through the oxidative addition of cobalt into the N-C(O) bond of phthalimide and the subsequent decarbonylation, we describe an efficient cobalt-catalyzed intermolecular decarbonylative carboamidation of alkynes. High regioselectivities have been achieved for unsymmetrical alkynes (including aryl-alkyl or aryl-aryl) to deliver polysubstituted isoquinolones. To facilitate step economy, a three-component decarbonylative carboamidation of alkynes with phthalic anhydrides and amines has been demonstrated using the current cobalt catalysis.
