l-Isoprenaline hydrochloride

Base Information

• Chemical Name: l-Isoprenaline hydrochloride
• CAS No.: 51-30-9
• Molecular Formula: C₁₁H₁₈NO₃*Cl
• Molecular Weight: 247.722
• Hs Code.: 29225090
• European Community (EC) Number: 213-438-4
• Pharos Ligand ID: 9F2V3V2MRJAL
• Mol file: 51-30-9.mol

Synonyms:l-Isoprenaline hydrochloride;[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-propan-2-ylazanium;chloride;EINECS 213-438-4;DL-4-(2-(Isopropylamino)-1-hydroxyethyl)pyrocatechol hydrochloride;(-)-3,4-Dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol hydrochloride;LS-42871;LS-42872;Benzyl alcohol, 3,4-dihydroxy-alpha-((isopropylamino)methyl)-, hydrochloride, (-)-

Chemical Property of l-Isoprenaline hydrochloride

Chemical Property:

• Appearance/Colour: white crystalline powder
• Melting Point: 165-175 °C (dec.)(lit.)
• Refractive Index: 1.6000 (estimate)
• Boiling Point: 417.5 °C at 760 mmHg
• Flash Point: 179.7 °C
• Density: 1.324 g/cm3
• Storage Temp.: Store at RT
• Solubility.: Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
• Water Solubility.: Soluble
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 247.0975211
• Heavy Atom Count: 16
• Complexity: 187

Purity/Quality:

99% ^*data from raw suppliers

Isoproterenol Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)[NH2+]CC(C1=CC(=C(C=C1)O)O)O.[Cl-]
• Uses: Isoproterenol is a non-selective beta-adrenergic agonist. Isoproterenol is used in the treatment of bradycardia; bronchodilator. Isoproterenol hydrochloride is used as a selective β-adrenergic agonist, increases cytosolic cAMP.

Technology Process of l-Isoprenaline hydrochloride

There total 6 articles about l-Isoprenaline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.3%

Isoproterenone hydrochloride (16899-81-3) → isoproterenol hydrochloride (51-30-9,949-36-0)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; pyrographite; In water; at 35 ℃; under 3750.38 Torr; Pressure; Temperature; Autoclave;

Reference yield: 85.7%

Isoproterenone (121-28-8) → isoproterenol hydrochloride (51-30-9,949-36-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 25 ℃; for 4h; Time;

Reference yield:

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → isoproterenol hydrochloride (51-30-9,949-36-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: zinc(II) chloride / 1,2-dichloro-ethane / 0.5 h / 10 - 15 °C

1.2: 20 h / 70 °C

2.1: triethylamine / ethanol / 10 h / 10 - 40 °C

3.1: pyrographite; 5%-palladium/activated carbon; hydrogen / water / 35 °C / 3750.38 Torr / Autoclave

With 5%-palladium/activated carbon; hydrogen; pyrographite; triethylamine; zinc(II) chloride; In ethanol; water; 1,2-dichloro-ethane;

upstream raw materials:

(-)-isoproterenol hydrochloride

Isoproterenone

Isoproterenone hydrochloride

benzene-1,2-diol

Downstream raw materials:

isoproterenol hydrochloride

(+)-Isoproterenol hydrochloride

(R)-(-)-isoproterenol hydrochloride

isoprenaline glucuronide

Refernces

• 1、 -. "Hydrochloric acid isopropyl adrenergic preparation method". Paragraph 0014; 0019-0021; 0026-0028; 0033-0034. . Retrieved 2019/03/31.
• 2、 Bosak, Anita,Smilovi?, Ivana Gazi?,?inko, Goran,Vinkovi?, Vladimir,Kovarik, Zrinka. "Metaproterenol, isoproterenol, and their bisdimethylcarbamate derivatives as human cholinesterase inhibitors". body text. p. 6716 - 6723. Retrieved 2012/09/22.