5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE

Base Information

• Chemical Name: 5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE
• CAS No.: 873107-98-3
• Molecular Formula: C6H3F3IN
• Molecular Weight: 272.996
• Hs Code.: 2933998090
• Mol file: 873107-98-3.mol

Synonyms:5-Iodo-2-(trifluoromethyl)pyridine;Pyridine, 5-iodo-2-(trifluoromethyl)-;LogP

Chemical Property of 5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE

Chemical Property:

• Vapor Pressure: 0.39mmHg at 25°C
• Boiling Point: 203.71°C at 760 mmHg
• PKA: -1.47±0.22(Predicted)
• Flash Point: 77.002°C
• PSA: 12.89000
• Density: 1.975g/cm³
• LogP: 2.70500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

5-Iodo-2-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Iodo-2-(trifluoromethyl)pyridine is a useful reactant for metal-catalyzed organic reactions.

Technology Process of 5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE

There total 2 articles about 5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

6-(trifluoromethyl)pyridin-3-amine (106877-33-2) → 5-iodo-2-(trifluoromethyl)pyridine (873107-98-3)

Guidance literature:

6-(trifluoromethyl)pyridin-3-amine; With hydrogenchloride; sodium nitrite; In water; at -5 - 5 ℃; for 0.166667h;

With potassium iodide; In water; at -5 - 10 ℃;

Reference yield: 82.0%

5-bromo-2(trifluoromethyl)pyridine (436799-32-5) → 5-iodo-2-(trifluoromethyl)pyridine (873107-98-3)

Guidance literature:

With copper(l) iodide; sodium iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 110 ℃; for 24h;

DOI:10.1002/anie.201812925

Reference yield: 97.1%

5-iodo-2-(trifluoromethyl)pyridine (873107-98-3) + Ethyl methyl sulfide (624-89-5) → (±)5-(1-(methylthio)ethyl)-2-trifluoromethyl pyridine

Guidance literature:

With triethylamine; In 5,5-dimethyl-1,3-cyclohexadiene; at 135 - 155 ℃; for 15.75h; under 2280.15 - 5320.36 Torr; Inert atmosphere;

upstream raw materials:

6-(trifluoromethyl)pyridin-3-amine

5-bromo-2(trifluoromethyl)pyridine

Downstream raw materials:

3,4-bis(benzyloxy)-6-{[6-(trifluoromethyl)pyridin-3-yl]ethynyl}pyridazine

Refernces

• 1、 -. "PYRROLOPYRIMIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS". Paragraph 0347. . Retrieved 2016/04/09.
• 2、 Kadunce, Nathaniel T.,Reisman, Sarah E.. "Nickel-Catalyzed Asymmetric Reductive Cross-Coupling between Heteroaryl Iodides and α-Chloronitriles". supporting information. p. 10480 - 10483. Retrieved 2015/09/28.