4-Bromo-2,6-Dichloropyridine

Base Information

• Chemical Name: 4-Bromo-2,6-Dichloropyridine
• CAS No.: 98027-80-6
• Molecular Formula: C5H2BrCl2N
• Molecular Weight: 226.888
• Hs Code.: 2933399090
• Mol file: 98027-80-6.mol

Synonyms:Pyridine, 4-bromo-2,5-dichloro-;

Chemical Property of 4-Bromo-2,6-Dichloropyridine

Chemical Property:

• Melting Point: 95℃
• Boiling Point: 254.3 °C at 760 mmHg
• PKA: -2.92±0.10(Predicted)
• Flash Point: 107.597 °C
• PSA: 12.89000
• Density: 1.848 g/cm³
• LogP: 3.15090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromo-2,6-dichloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2,6-Dichloropyridine

There total 1 articles about 4-Bromo-2,6-Dichloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dichloro-[4]pyridylamine (2587-02-2) → 4-bromo-2,6-dichloropyridine (98027-80-6)

Guidance literature:

With sulfuric acid; copper(II) sulfate; potassium bromide; sodium nitrite; at 60 ℃; Diazotization_.Reagens 4: Kupfer-Pulver; Reagens 5: Wasser;

Reference yield: 85.0%

4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine (882670-69-1) + 4-bromo-2,6-dichloropyridine (98027-80-6) → 3-(2,6-dichloropyridin-4-yl)-4-methylaniline

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; at 85 ℃; for 4h; Solvent; Inert atmosphere; Sealed tube;

Reference yield: 79.0%

4-bromo-2,6-dichloropyridine (98027-80-6) + cesium 2-(1-methylcyclohex-1-yl)oxy-2-oxoacetate + pinacol vinylboronate (75927-49-0) → 2,6-dichloro-4-(2-(1-methylcyclohexyl)ethyl)pyridine

Guidance literature:

With (1,2-dimethoxyethane)dichloronickel(II); [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine; In dimethyl sulfoxide; at 35 ℃; for 24h; Irradiation; Sealed tube; Inert atmosphere;

DOI:10.1055/a-1320-6946

upstream raw materials:

2,6-dichloro-[4]pyridylamine

Downstream raw materials:

2,3-dichloro-4-(3-chloro-4-fluoro-phenyl)-pyridine

2,6-dichloro-4-phenylpyridine

4-bromo-6-chloro-1-methylpyridin-2(1H)-one

Refernces