4-Amino-2,6-dichloropyridine

Base Information

• Chemical Name: 4-Amino-2,6-dichloropyridine
• CAS No.: 2587-02-2
• Molecular Formula: C5H4Cl2N2
• Molecular Weight: 163.006
• Hs Code.: 29333990
• Mol file: 2587-02-2.mol

Synonyms:Pyridine,4-amino-2,6-dichloro- (6CI,7CI,8CI);(2,6-Dichloropyridin-4-yl)amine;2,6-Dichloro-4-aminopyridine;2,6-Dichloropyridin-4-amine;NSC 136573;

Chemical Property of 4-Amino-2,6-dichloropyridine

Chemical Property:

• Appearance/Colour: white crystals
• Vapor Pressure: 0.00011mmHg at 25°C
• Melting Point: 169-173 °C(lit.)
• Boiling Point: 336.7 °C at 760 mmHg
• PKA: 0.49±0.50(Predicted)
• Flash Point: 157.4 °C
• PSA: 38.91000
• Density: 1.497 g/cm³
• LogP: 2.55180
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-2,6-dichloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 4-Amino-2,6-dichloropyridine

There total 18 articles about 4-Amino-2,6-dichloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

4-nitro-2,6-dichloro-pyridine (25194-01-8) → 2,6-dichloro-[4]pyridylamine (2587-02-2)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; at 95 ℃; for 16h;

Reference yield: 78.0%

2,6-dichloropyridine-4-carboxylic acid (5398-44-7) + trifluoroacetic acid (76-05-1) → 2,6-dichloro-[4]pyridylamine (2587-02-2)

Guidance literature:

2,6-dichloropyridine-4-carboxylic acid; trifluoroacetic acid; With sodium azide; oxalyl dichloride; In dichloromethane; Heating / reflux;

With potassium carbonate; In methanol;

Reference yield: 67.0%

2,4,6-trichloropyridine (16063-69-7) → 2,6-dichloro-[4]pyridylamine (2587-02-2) + 2-amino-4,6-dichloropyridine (116632-24-7)

Guidance literature:

With ammonium hydroxide; In water; at 130 ℃; for 4h;

DOI:10.1021/jm8005959

upstream raw materials:

2,4,6-trichloropyridine

2,6-dichloropyridine

2,6-dichloroisonicotinoyl chloride

4-nitro-2,6-dichloro-pyridine

Downstream raw materials:

2,6-dichloro-4-cyanopyridine

2,4,6-trichloropyridine

4-bromo-2,6-dichloropyridine

2,6-dichloro-4-iodopyridine

Refernces

• 1、 -. "Preparation method of 4-amino-2,6-dichloropyridine". . . Retrieved 2021/03/21.
• 2、 Gao, Hongyin,Zhou, Zhe,Kwon, Doo-Hyun,Coombs, James,Jones, Steven,Behnke, Nicole Erin,Ess, Daniel H.,Kürti, László. "Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds". . p. 681 - 688. Retrieved 2017/06/30.