2 6-DICHLORO-4-IODOPYRIDINE 97

Base Information

• Chemical Name: 2 6-DICHLORO-4-IODOPYRIDINE 97
• CAS No.: 98027-84-0
• Molecular Formula: C5H2Cl2IN
• Molecular Weight: 273.888
• Hs Code.: 29333990
• European Community (EC) Number: 627-336-6
• DSSTox Substance ID: DTXSID00471453
• Nikkaji Number: J1.537.718F
• Wikidata: Q72466566
• Mol file: 98027-84-0.mol

Synonyms:Octanedioic acid,1-methyl ester

Chemical Property of 2 6-DICHLORO-4-IODOPYRIDINE 97

Chemical Property:

• Appearance/Colour: Yellowish gray powder
• Vapor Pressure: 0.003mmHg at 25°C
• Melting Point: 161-165 °C
• Refractive Index: 1.652
• Boiling Point: 291.583 °C at 760 mmHg
• PKA: -3.19±0.10(Predicted)
• Flash Point: 130.145 °C
• PSA: 12.89000
• Density: 2.129 g/cm³
• LogP: 2.99300
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Light Sensitive
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 272.86090
• Heavy Atom Count: 9
• Complexity: 91

Purity/Quality:

99% ^*data from raw suppliers

2,6-Dichloro-4-iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41-43
• Safety Statements: 26-36-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(N=C1Cl)Cl)I

Technology Process of 2 6-DICHLORO-4-IODOPYRIDINE 97

There total 9 articles about 2 6-DICHLORO-4-IODOPYRIDINE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,6-dichloropyridine (2402-78-0) → 2,6-dichloro-4-iodopyridine (98027-84-0)

Guidance literature:

2,6-dichloropyridine; With N-tetramethylpiperidine magnesium chloride; lithium chloride; In tetrahydrofuran; at 25 ℃; for 0.1h;

With iodine; In tetrahydrofuran; at -30 ℃;

DOI:10.1002/anie.200504024

Reference yield: 93.0%

→ 2,6-dichloro-4-iodopyridine (98027-84-0)

Guidance literature:

Reference yield: 72.0%

2,6-dichloroisonicotinoyl chloride (42521-08-4) → 2,6-dichloro-4-iodopyridine (98027-84-0)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 150 ℃; for 12h;

DOI:10.1038/s41557-018-0078-8

upstream raw materials:

2,6-dichloro-[4]pyridylamine

2,6-dichloro-3-iodo-pyridine

2,6-dichloropyridine

methyl iodide

Downstream raw materials:

2,6-dichloro-4-phenylpyridine

2,4,6-trichloropyridine

(2,6-dichloropyridin-4-yl)boronic acid

6-chloro-N-cyclohexyl-4-(5H-pyrrolo[3,2-b]pyrazin-7-yl)pyridin-2-amine

Refernces

• 1、 Dierks, Philipp,P?pcke, Ayla,Bokareva, Olga S.,Altenburger, Bj?rn,Reuter, Thomas,Heinze, Katja,Kühn, Oliver,Lochbrunner, Stefan,Bauer, Matthias. "Ground- And Excited-State Properties of Iron(II) Complexes Linked to Organic Chromophores". . p. 14746 - 14761. Retrieved 2020.
• 2、 Hübscher, J?rg,Seichter, Wilhelm,Weber, Edwin. "Intermolecular contacts in the crystal structures of specifically varied halogen and protonic group substituted azines". . p. 3026 - 3036. Retrieved 2017/07/10.