2-Amino-3-cyano-5-methylpyrazine

Base Information

• Chemical Name: 2-Amino-3-cyano-5-methylpyrazine
• CAS No.: 17890-82-3
• Molecular Formula: C6H6N4
• Molecular Weight: 134.14
• Mol file: 17890-82-3.mol

Synonyms:3-Amino-6-methylpyrazine-2-carbonitrile;MD-0180;2-Amino-3-cyano-5-methylpyrazine;

Chemical Property of 2-Amino-3-cyano-5-methylpyrazine

Chemical Property:

• Appearance/Colour: White solid
• Melting Point: 172 °C
• Boiling Point: 348.9 °C at 760 mmHg
• PKA: 1.73±0.10(Predicted)
• Flash Point: 348.9 °C at 760 mmHg
• PSA: 75.59000
• Density: 1.27 g/cm³
• LogP: 0.82008
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-6-methylpyrazine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-3-cyano-5-methylpyrazine

There total 6 articles about 2-Amino-3-cyano-5-methylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-Amino-6-(carbomethoxy)-3-cyano-5-methylpyrazine (73198-31-9) → 3-amino-6-methylpyrazine-2-carbonitrile (17890-82-3)

Guidance literature:

With lithium iodide; In water; N,N-dimethyl-formamide; for 22h; Heating;

DOI:10.1021/jo01300a045

Reference yield: 80.0%

2-amino-3-bromo-5-methylpyrazine (74290-65-6) → 3-amino-6-methylpyrazine-2-carbonitrile (17890-82-3)

Guidance literature:

In N,N-dimethyl-formamide; at 120 - 130 ℃; for 2h;

DOI:10.1055/s-1990-26972

Reference yield: 80.0%

2-amino-3-bromo-5-methylpyrazine (74290-65-6) → 3-amino-6-methylpyrazine-2-carbonitrile (17890-82-3)

Guidance literature:

With sodium dicyano-cuprate; In N,N-dimethyl-formamide; at 120 - 130 ℃; for 2h; other 2-amino-3-bromopyrazines;

DOI:10.1055/s-1990-26972

upstream raw materials:

2-amino-3-bromo-5-methylpyrazine

2-Amino-6-(carbomethoxy)-3-cyano-5-methylpyrazine

2-Amino-6-(carbomethoxy)-3-cyano-5-methylpyrazine 1-oxide

3-amino-6-methyl-pyrazine-2-carboxylic acid amide

Refernces

• 1、 Sato, Nobuhiro,Takeuchi, Ryo. "Studies on Pyrazines; Part 20. A Simple Synthesis of 5-Substituted 2-Amino-3-cyanopyrazines: Useful Intermediates for Pteridine Synthesis". . p. 659 - 660. Retrieved 2007/10/02.
• 2、 Jones,Cragoe Jr.. "Pyrazine diuretics. V. N-Amidino-3-aminopyrazinecarboxamidines and analogous 2,4-diaminopteridines.". . p. 322 - 325. Retrieved 2007/10/08.