(R)-2,2-diphenylcyclopropanecarboxylic acid

Base Information

• Chemical Name: (R)-2,2-diphenylcyclopropanecarboxylic acid
• CAS No.: 53692-74-3
• Molecular Formula: C₁₆H₁₄O₂
• Molecular Weight: 238.286
• Mol file: 53692-74-3.mol

Synonyms:

Chemical Property of (R)-2,2-diphenylcyclopropanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2,2-diphenylcyclopropanecarboxylic acid

There total 7 articles about (R)-2,2-diphenylcyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-diphenyl-cyclopropanecarboxylic acid (7150-12-1) → (R)-2,2-diphenylcyclopropanecarboxylic acid (53692-74-3)

Guidance literature:

With brucine;

DOI:10.1021/ja01627a067

Reference yield:

2,2-diphenylcyclopropane-1-carbaldehyde (926905-41-1) → (R)-2,2-diphenylcyclopropanecarboxylic acid (53692-74-3)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide; In water; acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetasy.2006.11.027

Reference yield:

C16H14O2*C20H24N2O2 (1333307-67-7) → (R)-2,2-diphenylcyclopropanecarboxylic acid (53692-74-3)

Guidance literature:

With hydrogenchloride; In water; acetone; at 20 ℃; for 0.25h;

DOI:10.1002/hlca.201100135

upstream raw materials:

2,2-diphenyl-cyclopropanecarboxylic acid

1,1-Diphenylethylene

2,2-diphenylcyclopropane-1-carbaldehyde

3,3-diphenylprop-2-en-1-ol

Downstream raw materials:

methyl-2,2-diphenyl-cyclopropane carboxylate

3-((R)-2,2-Diphenyl-cyclopropanecarbonyl)-1,1-diethyl-thiourea

Toluene-4-sulfonic acid (R)-2,2-diphenyl-cyclopropylmethyl ester

(1R)-1,1-diphenyl-2-hydroxymethylcyclopropane

Refernces

• 1、 Koyata, Naka,Miura, Tsuyoshi,Akaiwa, Yoko,Sasaki, Hisashi,Sato, Rie,Nagai, Takuya,Fujimori, Hirohisa,Noguchi, Takuya,Kirihara, Masayuki,Imai, Nobuyuki. "Convenient preparation of optically active cibenzoline and analogues from 3,3-diaryl-2-propen-1-ols". experimental part. p. 2065 - 2071. Retrieved 2010/01/16.
• 2、 Kim, Hyun Chang,Choi, Soojin,Kim, Hongdoo,Ahn, Kwang-Hyun,Koh, Jeong Hwan,Park, Jaiwook. "Chiral 2,2-disubstituted cyclopropanecarboxylic acids: Effective derivatizing agents for analysis of enantiomeric purity of alcohols and for resolution of 1,1'-Bi-2-naphthol". . p. 3959 - 3962. Retrieved 2007/10/03.