N²-(4-n-Butylphenyl)-2'deoxy-3,5'-cycloguanosine

Base Information

• Chemical Name: N²-(4-n-Butylphenyl)-2'deoxy-3,5'-cycloguanosine
• CAS No.: 158729-54-5
• Molecular Formula: C₂₀H₂₃N₅O₃
• Molecular Weight: 381.434
• Mol file: 158729-54-5.mol

Synonyms:

Chemical Property of N²-(4-n-Butylphenyl)-2'deoxy-3,5'-cycloguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-(4-n-Butylphenyl)-2'deoxy-3,5'-cycloguanosine

There total 3 articles about N²-(4-n-Butylphenyl)-2'deoxy-3,5'-cycloguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.8%

Methylenediphosphonic acid (1984-15-2) + 5'-mesyl-N2-(p-n-butylphenyl)-2'-deoxyguanosine (160053-66-7) → N2-(4-n-Butylphenyl)-2'deoxy-3,5'-cycloguanosine (158729-54-5) + N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-(methylene)diphosphate

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; Yield given. Multistep reaction; 1.) H₂O, pH 7, 2.) MeCN, 3 days;

DOI:10.1080/15257779408013245

Reference yield: 30.4%

5'-mesyl-N2-(p-n-butylphenyl)-2'-deoxyguanosine (160053-66-7) → N2-(4-n-Butylphenyl)-2'deoxy-3,5'-cycloguanosine (158729-54-5) + N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-(methylene)diphosphate

Guidance literature:

With Methylenediphosphonic acid; tetra(n-butyl)ammonium hydroxide; In acetonitrile; for 72h;

DOI:10.1080/15257779408013245

Reference yield:

N2-(p-n-Butylphenyl)-9-(2-deoxy-β-D-ribofuranosyl)guanine (87781-96-2) → N2-(4-n-Butylphenyl)-2'deoxy-3,5'-cycloguanosine (158729-54-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / pyridine / 0.5 h / 0 °C

2: 67.8 percent / 1.) n-Bu₄NOH / 1.) H₂O, pH 7, 2.) MeCN, 3 days

With pyridine; tetra(n-butyl)ammonium hydroxide;

DOI:10.1080/15257779408013245

upstream raw materials:

Methylenediphosphonic acid

5'-mesyl-N²-(p-n-butylphenyl)-2'-deoxyguanosine

N2-(p-n-Butylphenyl)-9-(2-deoxy-β-D-ribofuranosyl)guanine

Refernces