tert-Butyl 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate

Base Information

• Chemical Name: tert-Butyl 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate
• CAS No.: 174486-93-2
• Molecular Formula: C12H22N2O2
• Molecular Weight: 226.31528
• Hs Code.: 2922498590
• Mol file: 174486-93-2.mol

Synonyms:3-Amino-8-Boc-8-azabicyclo[3.2.1]octane;8-Boc-3-aMino-8-azabicyclo[3.2.1]octane;3-AMino-8-aza-bicyclo[3.2.1]octane-8-carboxylic;tert-butyl 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate;tert-Butyl 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate 95+%;3-Amino-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester;8-Azabicyclo[3.2.1]octane-8-carboxylic acid, 3-amino-, 1,1-dimethylethyl ester

Chemical Property of tert-Butyl 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.508
• Boiling Point: 313.215 °C at 760 mmHg
• PKA: 10.12±0.20(Predicted)
• Flash Point: 143.227 °C
• PSA: 55.56000
• Density: 1.084g/cm³
• LogP: 2.51380
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl3-Amino-8-azabicyclo[3.2.1]octane-8-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate

There total 36 articles about tert-Butyl 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 3-(hydroxyimino)-8-azabicyclo[3.2.1]octane-8-carboxylate (913575-12-9) → (rac)-3-endo-3-amino-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (174486-93-2)

Guidance literature:

With hydrogen; acetic acid; platinum(IV) oxide; In ethanol; at 20 ℃;

Reference yield: 100.0%

(rac)-3-[(Z)-hydroxyimino]-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester → tert-butyl 3-endo-amino-8-azabicyclo[3.2.1]octane-8-carboxylate (207405-68-3,174486-93-2)

Guidance literature:

With hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; In ethanol; at 20 ℃;

Reference yield: 100.0%

Boc-tropinone (185099-67-6) → 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (174486-93-2)

Guidance literature:

With ammonium acetate; sodium cyanoborohydride; In methanol; for 2h; Reflux;

upstream raw materials:

3-amino-8-azabicyclo[3.2.1] octane

di-tert-butyl dicarbonate

Boc-tropinone

tert-butyl 3-(hydroxyimino)-8-azabicyclo[3.2.1]octane-8-carboxylate

Downstream raw materials:

Velusetrag

3,5-dichlorobenzyl 8-azabicyclo[3.2.1]octan-3-ylcarbamate hydrochloride

endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate

C₂₃H₃₀N₆O₆S

Refernces

• 1、 Xu, Jun,Yang, Tianjiao,Wang, Jiayi,Song, Gonghua. "Multistep Synthesis and Nematicidal Activity of 2-(8-azabicyclo[3.2.1]octan-3-yl)-3-imino-2,3-dihydro-1H-isoindol-1-One Derivatives". . p. 31 - 39. Retrieved 2021/02/12.
• 2、 Fang, Yuanying,Xiong, Lijuan,Hu, Jianguo,Zhang, Shaokun,Xie, Saisai,Tu, Liangxing,Wan, Yang,Jin, Yi,Li, Xiang,Hu, Shaojie,Yang, Zunhua. "Synthesis and evaluation of novel fused pyrimidine derivatives as GPR119 agonists". . p. 103 - 111. Retrieved 2019/01/28.