Technology Process of methyl 4-(3-hydroxypropyl)-3-(tosyloxy)cyclohexanecarboxylate
There total 5 articles about methyl 4-(3-hydroxypropyl)-3-(tosyloxy)cyclohexanecarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: H2 / 5percent Rh/Al2O3 / methanol / 24 h / 25 °C / 2585.7 Torr
2: H2SO4 / 20 h / Heating
3: Celite, pyridinium chlorochromate (PCC) / CH2Cl2 / 3 h / 25 °C
4: 1.) 2,2-dimethoxypropane, p-toluenesulfonic acid, 2.) NaBH4 / 1.) benzene, reflux, 2.) methanol, 0 deg C, 30 min
5: 55 percent / pyridine / 144 h / 25 °C
6: 1.) diborane, 2.) 20percent aq. NaOH, 30percent aq. H2O2 / 1.) THF, 0 deg C, 1 h, 2.) THF
With
pyridine; sodium hydroxide; sodium tetrahydroborate; Celite; sulfuric acid; hydrogen; dihydrogen peroxide; toluene-4-sulfonic acid; 2,2-dimethoxy-propane; pyridinium chlorochromate; diborane;
Rh/Al2O3;
In
methanol; dichloromethane;
DOI:10.1021/jo00362a012
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Celite, pyridinium chlorochromate (PCC) / CH2Cl2 / 3 h / 25 °C
2: 1.) 2,2-dimethoxypropane, p-toluenesulfonic acid, 2.) NaBH4 / 1.) benzene, reflux, 2.) methanol, 0 deg C, 30 min
3: 55 percent / pyridine / 144 h / 25 °C
4: 1.) diborane, 2.) 20percent aq. NaOH, 30percent aq. H2O2 / 1.) THF, 0 deg C, 1 h, 2.) THF
With
pyridine; sodium hydroxide; sodium tetrahydroborate; Celite; dihydrogen peroxide; toluene-4-sulfonic acid; 2,2-dimethoxy-propane; pyridinium chlorochromate; diborane;
In
dichloromethane;
DOI:10.1021/jo00362a012
- Guidance literature:
-
Multi-step reaction with 5 steps
1: H2SO4 / 20 h / Heating
2: Celite, pyridinium chlorochromate (PCC) / CH2Cl2 / 3 h / 25 °C
3: 1.) 2,2-dimethoxypropane, p-toluenesulfonic acid, 2.) NaBH4 / 1.) benzene, reflux, 2.) methanol, 0 deg C, 30 min
4: 55 percent / pyridine / 144 h / 25 °C
5: 1.) diborane, 2.) 20percent aq. NaOH, 30percent aq. H2O2 / 1.) THF, 0 deg C, 1 h, 2.) THF
With
pyridine; sodium hydroxide; sodium tetrahydroborate; Celite; sulfuric acid; dihydrogen peroxide; toluene-4-sulfonic acid; 2,2-dimethoxy-propane; pyridinium chlorochromate; diborane;
In
dichloromethane;
DOI:10.1021/jo00362a012