N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide

Base Information

• Chemical Name: N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
• CAS No.: 925434-55-5
• Molecular Formula: C₂₅H₂₃N₇OS
• Molecular Weight: 469.57
• Hs Code.: 2934100090
• Mol file: 925434-55-5.mol

Synonyms:N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide;

Chemical Property of N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide

Chemical Property:

• Melting Point: 221°C
• PKA: 11.19±0.70(Predicted)
• PSA: 115.69000
• Density: 1.46g/cm³
• LogP: 4.00320
• Storage Temp.: -20C

Purity/Quality:

99% ^*data from raw suppliers

SRT1720 - CAS 925434-55-5 - CalbiochemSRT1720, CAS 925434-55-5, is a cell-permeable inhibitor of the mitochondrial SIRT3. Inhibition is AceCS2-competitive (Ki = 0.56 μM; Km = 2.44 μM), but NAD+-uncompetitive (Ki = 0.34 μM; Km = 280 μM). ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide

There total 8 articles about N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C30H31N7O3S (925436-46-0) → SRT1720 (925434-55-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield:

C2HF3O2*C25H23N7OS (1093403-41-8) → SRT1720 (925434-55-5)

Guidance literature:

With sodium hydrogencarbonate; In water;

DOI:10.1021/jm8012954

Reference yield:

(6-(2-nitrophenyl)imidazo[2,1-b]thiazol-3-yl)methanol (925437-85-0) → SRT1720 (925434-55-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.25 h / 20 °C

2.1: triethylamine / acetonitrile / 24 h / 20 °C

2.2: 24 h / Heating / reflux

3.1: pyridine / 0.17 h / 160 °C / microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 2 h

With pyridine; triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;

upstream raw materials:

C₃₀H₃₁N₇O₃S

C₂HF₃O₂*C₂₅H₂₃N₇OS

quinoxaline-2-carboxylic acid chloride

4-[6-(2-aminophenyl)imidazo[2,1-b]thiazol-3-ylmethyl]piperazine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "SIRTUIN MODULATING IMIDAZOTHIAZOLE COMPOUNDS". Page/Page column 74. . Retrieved 2009/01/23.