(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride

Base Information

• Chemical Name: (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride
• CAS No.: 173897-44-4
• Molecular Formula: C₁₆H₁₆N₄O*ClH
• Molecular Weight: 316.79
• Mol file: 173897-44-4.mol

Synonyms:(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride;Y 39983, 2 HCl salt

Chemical Property of (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride

Chemical Property:

• PSA: 83.80000
• LogP: 5.21220
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Soluble in DMSO

Purity/Quality:

99.3% ^*data from raw suppliers

Y-39983Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Y-39983 Hydrochloride contain Rho kinase inhibitory activity.

Technology Process of (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride

There total 7 articles about (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

→ 4-(1-amino-ethyl)-N-(1H-pyrrolo[2,3]pyridin-4-yl)-benzamide dihydrochloride (173897-44-4)

Guidance literature:

Reference yield:

(R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride (173897-73-9) → Y-39983 (471843-75-1,173897-44-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 8 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: hydrogenchloride; 10% palladium hydroxide on charcoal; hydrogen / methanol / 1 h / 40 °C

3.1: sodium hydroxide / water / Cooling with ice

4.1: hydrogenchloride / ethanol / 3.5 h / 20 - 60 °C / Cooling with ice

With hydrogenchloride; 10% palladium hydroxide on charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; ethanol; water; acetonitrile;

Reference yield:

(R)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-benzyloxycarbonylaminoethyl)benzamide (173897-93-3) → Y-39983 (471843-75-1,173897-44-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; 10% palladium hydroxide on charcoal; hydrogen / methanol / 1 h / 40 °C

2: sodium hydroxide / water / Cooling with ice

3: hydrogenchloride / ethanol / 3.5 h / 20 - 60 °C / Cooling with ice

With hydrogenchloride; 10% palladium hydroxide on charcoal; hydrogen; sodium hydroxide; In methanol; ethanol; water;

upstream raw materials:

(R)-(+)-4-(1-benzyloxycarbonylaminoethyl)-benzoic acid

(R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride

(R)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-benzyloxycarbonylaminoethyl)benzamide

Refernces

• 1、 -. "KINASE INHIBITORS". Page/Page column 68. . Retrieved 2008/06/13.