(R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride

Base Information

• Chemical Name: (R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride
• CAS No.: 173897-73-9
• Molecular Formula: C₁₇H₁₆ClNO₃
• Molecular Weight: 317.772
• Mol file: 173897-73-9.mol

Synonyms:(R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride

Chemical Property of (R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride

There total 1 articles about (R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-(+)-4-(1-benzyloxycarbonylaminoethyl)-benzoic acid (173898-15-2) → (R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride (173897-73-9)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In Dichlorodifluoromethane; for 1h; Heating / reflux;

Reference yield:

(R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride (173897-73-9) + 4-amino-1H-pyrrolo<2,3-b>pyridine (74420-00-1) → (R)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-benzyloxycarbonylaminoethyl)benzamide (173897-93-3)

Guidance literature:

(R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride; 4-amino-1H-pyrrolo<2,3-b>pyridine; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 1h;

With sodium methylate; In methanol; at 20 ℃; for 0.5h;

Reference yield:

4-aminopyridine (504-24-5) + (R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride (173897-73-9) → (R)-N-(pyridin-4-yl)-4-(1-benzyloxycarbonylaminoethyl)benzamide (173897-74-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 5h;

upstream raw materials:

(R)-(+)-4-(1-benzyloxycarbonylaminoethyl)-benzoic acid

Downstream raw materials:

(R)-N-(pyridin-4-yl)-4-(1-benzyloxycarbonylaminoethyl)benzamide

(R)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-benzyloxycarbonylaminoethyl)benzamide

(R)-N-(1H-pyrazolo[3,4-b]pyridin-4-yl)-4-(1-benzyloxycarbonylaminoethyl)benzamide

(R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide dihydrochloride

Refernces

• 1、 -. "N-heterocyclic substituted benzamide derivatives with antihypertensive activity". Page 48. . Retrieved 2008/06/13.