Tridesmethylvenlafaxine

Base Information Edit

Chemical Name:Tridesmethylvenlafaxine
CAS No.:149289-29-2
Molecular Formula:C14H21NO2
Molecular Weight:235.326
Hs Code.:
European Community (EC) Number:812-270-4
UNII:L00G2AX0BL
DSSTox Substance ID:DTXSID201344201
Nikkaji Number:J393.603A
Wikidata:Q27282532
Mol file:149289-29-2.mol

Synonyms:149289-29-2;Tridesmethylvenlafaxine;N,N,O-Tridesmethylvenlafaxine;4-[2-amino-1-(1-hydroxycyclohexyl)ethyl]phenol;D,L-N,N-Didesmethyl-O-desmethyl Venlafaxine;1-[2-amino-1-(4-hydroxyphenyl)ethyl]cyclohexanol;o-Desmethyl-N,N-didesmethylvenlafaxine;4-(2-amino-1-(1-hydroxycyclohexyl)ethyl)phenol;UNII-L00G2AX0BL;L00G2AX0BL;N,N,O-Tridesmethyl-venlafaxine;1-(2-Amino-1-(4-hydroxyphenyl)ethyl)cyclohexanol;Phenol, 4-(2-amino-1-(1-hydroxycyclohexyl)ethyl)-;SCHEMBL1699450;DIDESMETHYL DESVENLAFAXINE;DTXSID201344201;ZFA28929;Wy-46965;AKOS040759786;HY-W049735;MS-23362;CS-0103531;FT-0760344;D76368;Q27282532

Suppliers and Price of Tridesmethylvenlafaxine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
D,L-N,N-Didesmethyl-O-desmethylVenlafaxine
2.5mg
$ 175.00

ChemScene
N,N,O-Tridesmethylvenlafaxine
100mg
$ 500.00

American Custom Chemicals Corporation
D,L-N,N-DIDESMETHYL-O-DESMETHYL VENLAFAXINE 95.00%
5MG
$ 499.39

Total 34 raw suppliers

Chemical Property of Tridesmethylvenlafaxine Edit

Chemical Property:

Boiling Point:405.0±20.0 °C(Predicted)
PKA:9.72±0.26(Predicted)
PSA：66.48000
Density:1.179
LogP:2.83000
Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:2.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:235.157228913
Heavy Atom Count:17
Complexity:230

Purity/Quality:

99% ^*data from raw suppliers

D,L-N,N-Didesmethyl-O-desmethylVenlafaxine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)(C(CN)C2=CC=C(C=C2)O)O
Uses D,L-N,N-Didesmethyl-O-desmethyl Venlafaxine is a metabolite of Venlafaxine (V120000), a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant.

Technology Process of Tridesmethylvenlafaxine

There total 10 articles about Tridesmethylvenlafaxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

: C₁₄H₁₅NO₂

: 149289-29-2
N,N-Didesmethyldesvenlafaxine

Guidance literature:: With ethanol; hydrogen; nickel; potassium hydroxide; at 55 - 70 ℃; for 10h; under 30003 - 37503.8 Torr; Temperature; Autoclave;

Reference yield: 91.0%

: 130198-05-9
1-[2-amino-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride

: 149289-29-2
N,N-Didesmethyldesvenlafaxine

Guidance literature:: 1-[2-amino-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride; With sodium sulfide hydrate; In 1-methyl-pyrrolidin-2-one; at 20 - 185 ℃;

With succinic acid; In 1-methyl-pyrrolidin-2-one; water; at 10 - 90 ℃; pH=10 - 11;

Reference yield: 89.63%

: 93413-77-5,272788-06-4,273720-73-3,149289-31-6
N,N-didesmethylvenlafaxine

: 149289-29-2
N,N-Didesmethyldesvenlafaxine

Guidance literature:: N,N-didesmethylvenlafaxine; With sodium tri-sec-butylborohydride; In tetrahydrofuran; toluene; at 20 - 115 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; toluene; at 10 ℃; pH=1.0; Reflux;

With sodium hydroxide; In water; at 20 ℃; pH=10.3 - 10.5; Product distribution / selectivity;