4-Piperidinone,3-fluoro

Base Information

• Chemical Name: 4-Piperidinone,3-fluoro
• CAS No.: 1070955-78-0
• Molecular Formula: C5H8FNO
• Molecular Weight: 117.1215232
• Mol file: 1070955-78-0.mol

Synonyms:4-Piperidinone,3-fluoro;3-Fluoro-4-piperidinone;3-fluoropiperidin-4-one

Chemical Property of 4-Piperidinone,3-fluoro

Chemical Property:

• Boiling Point: 172.377 °C at 760 mmHg
• PKA: 6.92±0.40(Predicted)
• Flash Point: 58.052 °C
• PSA: 29.10000
• Density: 1.133 g/cm³
• LogP: 0.21570
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Fluoropiperidin-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperidinone,3-fluoro

There total 1 articles about 4-Piperidinone,3-fluoro which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate (211108-50-8) → 3-fluoropiperidin-4-one (1070955-78-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield: 3.0%

3-fluoropiperidin-4-one (1070955-78-0) + benzyl bromide (100-39-0) → 1-benzyl-3-fluoropiperidin-4-one

Guidance literature:

3-fluoropiperidin-4-one; With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

benzyl bromide; With potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2019.126933

Reference yield:

3-fluoropiperidin-4-one (1070955-78-0) → (9H-fluoren-9-yl)methyl (3R,4S)-3-fluoro-4-{[(4-fluorophenyl)methyl]amino}piperidine-1-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 20 h / 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 4 h

With pyridine; sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane;

upstream raw materials:

tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate

Refernces