4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonami de

Base Information

• Chemical Name: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonami de
• CAS No.: 194044-54-7
• Molecular Formula: C17H14F3N3O2S
• Molecular Weight: 0
• Mol file: 194044-54-7.mol

Synonyms:4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide;Ccris 9330;Hsdb 7038;p-(5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide

Chemical Property of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonami de

Chemical Property:

• Melting Point: 157-159oC
• Boiling Point: 529oC at 760 mmHg
• Flash Point: 273.7oC
• PSA: 86.36000
• Density: 1.43 g/cm3
• LogP: 5.29500

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonami de

There total 88 articles about 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonami de which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N,N-dibenzyl-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (853793-24-5) → 4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide (169590-42-5,194044-54-7)

Guidance literature:

With sulfuric acid; at 20 ℃; for 8h;

DOI:10.1016/j.tet.2015.09.007

Reference yield: 99.0%

4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione (720-94-5) + 4-hydrazinobenzene-1-sulfonamide hydrochloride (17852-52-7,27918-19-0) → 4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide (169590-42-5,194044-54-7)

Guidance literature:

at 90 ℃; Temperature;

Reference yield: 98.8%

4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione (720-94-5) + 4-hydrazinobenzene-1-sulfonamide hydrochloride → 4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide (169590-42-5,194044-54-7)

Guidance literature:

In ethanol; for 24h; Solvent; Inert atmosphere; Reflux;

upstream raw materials:

4-[5-(4-methylphenyl)-3-trifluoromethyl-1H-pyrazol-1-yl]benzenesulfonyl chloride

4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione

4-hydrazinobenzene-1-sulfonamide hydrochloride

methyl iodide

Downstream raw materials:

C₂₆H₂₂F₃N₃O₃S

C₂₆H₂₁F₃N₄O₅S

C₂₅H₁₉F₃N₄O₅S

Refernces

• 1、 Liu, Yongan,Pan, Qijun,Hu, Xiaojun,Guo, Yong,Chen, Qing-Yun,Liu, Chao. "Rapid Access to N-Protected Sulfonimidoyl Fluorides: Divergent Synthesis of Sulfonamides and Sulfonimidamides". . p. 3975 - 3980. Retrieved 2021/05/26.
• 2、 Wan, Chao,Pang, Jian-Yu,Jiang, Wei,Zhang, Xiao-Wei,Hu, Xiang-Guo. "Copper-Catalyzed Reductive Ring-Cleavage of Isoxazoles: Synthesis of Fluoroalkylated Enaminones and Application for the Preparation of Celecoxib, Deracoxib, and Mavacoxib". . p. 4557 - 4566. Retrieved 2021/03/01.