C₂₆H₃₀F₇N₃O

Base Information

• Chemical Name: C₂₆H₃₀F₇N₃O
• CAS No.: 578710-94-8
• Molecular Formula: C₂₆H₃₀F₇N₃O
• Molecular Weight: 533.533
• Mol file: 578710-94-8.mol

Synonyms:

Chemical Property of C₂₆H₃₀F₇N₃O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₀F₇N₃O

There total 6 articles about C₂₆H₃₀F₇N₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide (414910-03-5) + dimethyl amine (124-40-3) → C26H30F7N3O (578710-96-0) + C26H30F7N3O (578710-94-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; In acetonitrile; at 20 ℃; for 24h; optical yield given as %de; Inert atmosphere;

DOI:10.1021/jm1013264

Reference yield:

4-methoxypyridine (620-08-6,1232006-56-2) → C26H30F7N3O (578710-96-0) + C26H30F7N3O (578710-94-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: iodine; magnesium / tetrahydrofuran / 35 - 70 °C / Inert atmosphere; Reflux; Large scale reaction

1.2: -20 - 30 °C / Inert atmosphere; Large scale reaction

2.1: Wilkinson's catalyst; hydrogen / isopropyl alcohol / 5 h / 50 - 60 °C / 3750.38 Torr / Inert atmosphere; Large scale reaction

3.1: 5% Pd(II)/C(eggshell); hydrogen / isopropyl alcohol / 5 h / 20 °C / 3000.3 Torr / Inert atmosphere; Large scale reaction

3.2: Inert atmosphere; Large scale reaction

4.1: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / Inert atmosphere; Large scale reaction

4.2: 20 °C / Inert atmosphere; Large scale reaction

5.1: sodium carbonate / water; ethyl acetate / 0.25 h / 20 °C

5.2: 0.25 h / Inert atmosphere

5.3: 5.25 h / 10 °C / Reflux; Inert atmosphere

6.1: sodium tris(acetoxy)borohydride / acetonitrile / 24 h / 20 °C / Inert atmosphere

With Wilkinson's catalyst; 5% Pd(II)/C(eggshell); hydrogen; iodine; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; sodium carbonate; magnesium; In tetrahydrofuran; dichloromethane; water; ethyl acetate; isopropyl alcohol; acetonitrile; 1.2: Comins type reaction;

DOI:10.1021/jm1013264

Reference yield:

phenylmethyl 2-(4-fluoro-2-methylphenyl)-4-oxo-3,4-dihydro-1(2H)-pyridinecarboxylate (414909-98-1) → C26H30F7N3O (578710-96-0) + C26H30F7N3O (578710-94-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: Wilkinson's catalyst; hydrogen / isopropyl alcohol / 5 h / 50 - 60 °C / 3750.38 Torr / Inert atmosphere; Large scale reaction

2.1: 5% Pd(II)/C(eggshell); hydrogen / isopropyl alcohol / 5 h / 20 °C / 3000.3 Torr / Inert atmosphere; Large scale reaction

2.2: Inert atmosphere; Large scale reaction

3.1: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / Inert atmosphere; Large scale reaction

3.2: 20 °C / Inert atmosphere; Large scale reaction

4.1: sodium carbonate / water; ethyl acetate / 0.25 h / 20 °C

4.2: 0.25 h / Inert atmosphere

4.3: 5.25 h / 10 °C / Reflux; Inert atmosphere

5.1: sodium tris(acetoxy)borohydride / acetonitrile / 24 h / 20 °C / Inert atmosphere

With Wilkinson's catalyst; 5% Pd(II)/C(eggshell); hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; sodium carbonate; In dichloromethane; water; ethyl acetate; isopropyl alcohol; acetonitrile;

DOI:10.1021/jm1013264

upstream raw materials:

4-methoxypyridine

phenylmethyl 2-(4-fluoro-2-methylphenyl)-4-oxo-3,4-dihydro-1(2H)-pyridinecarboxylate

(2R)-2-(4-fluoro-2-methylphenyl)-4-piperidinone L-(+)-mandelate

(2R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide

Refernces