Technology Process of (5RS,6SR)-5-iodo-6-phenyltetrahydro-2H-pyran-2-one
There total 11 articles about (5RS,6SR)-5-iodo-6-phenyltetrahydro-2H-pyran-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-iodo-succinimide; tri-n-butylphosphine sulfide; trifluoroacetic acid;
In
dichloromethane;
at -45 ℃;
for 2h;
regioselective reaction;
Inert atmosphere;
Darkness;
DOI:10.1073/pnas.1005296107
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: phosphorus tribromide / diethyl ether / 0 °C / Inert atmosphere; Darkness
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
2.2: 20 h / 0 - 20 °C
3.1: potassium hydroxide / methanol; water / 21 h / 110 °C
3.2: 170 - 190 °C
4.1: (Z)-1-benzylcyclooct-1-ene / dichloromethane / 0.5 h / -20 °C
4.2: 6 h / -20 °C
With
(Z)-1-benzylcyclooct-1-ene; phosphorus tribromide; sodium hydride; potassium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; mineral oil;
DOI:10.1002/anie.201808320
- Guidance literature:
-
With
N-iodo-succinimide; Tributylphosphine oxide;
In
dichloromethane;
at -45 ℃;
for 3h;
regioselective reaction;
DOI:10.1073/pnas.1005296107