Technology Process of 2-(2-{2-[3-(4-fluoro-phenyl)-3-phenyl-propyl]-1H-imidazol-4-yl}-ethyl)-isoindole-1,3-dione
There total 7 articles about 2-(2-{2-[3-(4-fluoro-phenyl)-3-phenyl-propyl]-1H-imidazol-4-yl}-ethyl)-isoindole-1,3-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: NaH; NaI / dimethylformamide
1.2: dimethylformamide / 38 h / 60 - 90 °C
2.1: aq. KOH / ethanol / 12 h / Heating
3.1: 0.17 h / 180 °C
4.1: LiAlH4 / diethyl ether
5.1: SOCl2; 4-DMAP / CH2Cl2
6.1: KI / dimethylsulfoxide / 5 h / 20 - 95 °C
7.1: SOCl2 / 168 h / -30 °C
8.1: liq. NH3 / 18 h / 20 - 60 °C / 18001.4 - 19501.6 Torr
With
dmap; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ammonia; sodium hydride; potassium iodide; sodium iodide;
In
diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
1.1: Metallation / 1.2: Substitution / 2.1: Hydrolysis / 3.1: Decarboxylation / 4.1: Reduction / 5.1: Substitution / 6.1: Substitution / 7.1: Addition / 8.1: cyclocondensation;
DOI:10.1016/S0223-5234(00)00105-7
- Guidance literature:
-
Multi-step reaction with 5 steps
1: LiAlH4 / diethyl ether
2: SOCl2; 4-DMAP / CH2Cl2
3: KI / dimethylsulfoxide / 5 h / 20 - 95 °C
4: SOCl2 / 168 h / -30 °C
5: liq. NH3 / 18 h / 20 - 60 °C / 18001.4 - 19501.6 Torr
With
dmap; lithium aluminium tetrahydride; thionyl chloride; ammonia; potassium iodide;
In
diethyl ether; dichloromethane; dimethyl sulfoxide;
1: Reduction / 2: Substitution / 3: Substitution / 4: Addition / 5: cyclocondensation;
DOI:10.1016/S0223-5234(00)00105-7
- Guidance literature:
-
Multi-step reaction with 3 steps
1: KI / dimethylsulfoxide / 5 h / 20 - 95 °C
2: SOCl2 / 168 h / -30 °C
3: liq. NH3 / 18 h / 20 - 60 °C / 18001.4 - 19501.6 Torr
With
thionyl chloride; ammonia; potassium iodide;
In
dimethyl sulfoxide;
1: Substitution / 2: Addition / 3: cyclocondensation;
DOI:10.1016/S0223-5234(00)00105-7