sodium (+/-)-erythro-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-8-(1-methyl-1H-tetrazol-5-yl)-6,8-nonadienoate

Base Information

• Chemical Name: sodium (+/-)-erythro-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-8-(1-methyl-1H-tetrazol-5-yl)-6,8-nonadienoate
• CAS No.: 130320-56-8
• Molecular Formula: C₂₃H₂₁F₂N₄O₄*Na
• Molecular Weight: 478.431
• Mol file: 130320-56-8.mol

Synonyms:

Chemical Property of sodium (+/-)-erythro-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-8-(1-methyl-1H-tetrazol-5-yl)-6,8-nonadienoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of sodium (+/-)-erythro-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-8-(1-methyl-1H-tetrazol-5-yl)-6,8-nonadienoate

There total 14 articles about sodium (+/-)-erythro-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-8-(1-methyl-1H-tetrazol-5-yl)-6,8-nonadienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl (+/-)-erythro-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-8-(1-methyl-1H-tetrazol-5-yl)-6,8-nonadienoate (118874-96-7,118875-42-6,130273-25-5) → sodium (+/-)-erythro-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-8-(1-methyl-1H-tetrazol-5-yl)-6,8-nonadienoate (118845-47-9,118918-04-0,118919-06-5,130200-44-1,130320-56-8,130320-57-9,131177-45-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1021/jm00173a013

Reference yield:

trans-(4R,6S)-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-hydroxy-2H-pyran-2-one (118918-05-1) → BMY-21950 (130320-56-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jm00173a013

Reference yield:

cis-(4R,6S)-2,2-dimethyl-6-formyl-1,3-dioxane-4-acetic acid (123185-91-1) → BMY-21950 (130320-56-8)

Guidance literature:

Multi-step reaction with 5 steps

1: n-BuLi / tetrahydrofuran; hexane / -78 °C

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) a) -78 deg C, 30 min, b) RT, 16 h

3: 0.2 N HCl / tetrahydrofuran / 16 h

4: 1-cyclohexyl-3-(2-morpholinomethyl)carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 4 h

5: aq. NaOH / tetrahydrofuran / Ambient temperature

With hydrogenchloride; sodium hydroxide; n-butyllithium; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jm00173a013

upstream raw materials:

ethyl (+/-)-erythro-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-8-(1-methyl-1H-tetrazol-5-yl)-6,8-nonadienoate

trans-(4R,6S)-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-hydroxy-2H-pyran-2-one

cis-(4R,6S)-2,2-dimethyl-6-formyl-1,3-dioxane-4-acetic acid

methyl (3S^*,5R^*)-3,5-isopropylidenedioxy-7-phenyl-6-heptenoate

Refernces