1-Methylphenazine

Base Information

• Chemical Name: 1-Methylphenazine
• CAS No.: 1016-59-7
• Molecular Formula: C13H10N2
• Molecular Weight: 194.236
• DSSTox Substance ID: DTXSID90345735
• Nikkaji Number: J103.994F
• Wikidata: Q82118422
• ChEMBL ID: CHEMBL1344088
• Mol file: 1016-59-7.mol

Synonyms:1-Methylphenazine;1016-59-7;Phenazine, 1-methyl-;Methylphenazin;1-methyl phenazine;1-methyl-phenazine;MLS001005718;SCHEMBL183009;CHEMBL1344088;WBVSERCLMQZOBK-UHFFFAOYSA-;DTXSID90345735;HMS2723O17;AKOS003627836;SMR000348973;A854370;AF-407/09202012

Chemical Property of 1-Methylphenazine

Chemical Property:

• PSA: 25.78000
• LogP: 3.09140
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 194.084398327
• Heavy Atom Count: 15
• Complexity: 229

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-METHYLPHENAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=CC2=NC3=CC=CC=C3N=C12

Technology Process of 1-Methylphenazine

There total 23 articles about 1-Methylphenazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

phenazine-1-carboxylic acid methyl ester (3225-19-2) → 1-methyl-phenazine (1016-59-7)

Guidance literature:

With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at -5 - 20 ℃; for 4h;

Reference yield: 80.0%

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) + 3-methyl-1,2-benzenediamine (2687-25-4) → 1-methyl-phenazine (1016-59-7)

Guidance literature:

benzene-1,2-diol; 3-methyl-1,2-benzenediamine; at 210 - 220 ℃; for 10h; Inert atmosphere;

With air; at 210 - 220 ℃; for 3h;

DOI:10.14233/ajchem.2015.18757

Reference yield: 66.0%

N-(3-methylphenyl)-N-(2-nitrosophenyl)amine → 1-methyl-phenazine (1016-59-7) + 2-methylphenazine (1016-94-0)

Guidance literature:

With N,O-bis-(trimethylsilyl)-acetamide; In N,N-dimethyl-formamide; at 20 ℃; for 22h;

DOI:10.1016/j.tet.2017.04.046

upstream raw materials:

1-methyl-1,2,3,4-tetrahydrophenazine

2-methyl-N-(2-nitrophenyl)aniline

N-o-tolyl-o-phenylenediamine

nitrobenzene

Downstream raw materials:

tubermycin B

1,5-dimethyl-phenazinium; methyl sulfate

Refernces

• 1、 Clemo,McIlwain. "-". . p. 1991. Retrieved 1934.
• 2、 Mermod. "-". . p. 362. Retrieved 1935.
• 3、 -. "Preparation method of 1-methylphenazine". Paragraph 0016; 0017; 0018. . Retrieved 2018/05/16.