β-cyanoethyl ester of N-benzoyl-2',3'-di-O-benzoylcytidine 5'--1-phosphate

Base Information

• Chemical Name: β-cyanoethyl ester of N-benzoyl-2',3'-di-O-benzoylcytidine 5'--1-phosphate
• CAS No.: 74307-76-9
• Molecular Formula: C₄₁H₄₂N₅O₁₂P
• Molecular Weight: 827.785
• Mol file: 74307-76-9.mol

Synonyms:

Chemical Property of β-cyanoethyl ester of N-benzoyl-2',3'-di-O-benzoylcytidine 5'--1-phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of β-cyanoethyl ester of N-benzoyl-2',3'-di-O-benzoylcytidine 5'--1-phosphate

There total 6 articles about β-cyanoethyl ester of N-benzoyl-2',3'-di-O-benzoylcytidine 5'--1-phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.7%

cis-(N-4-hydroxycyclohexyl)acetamide (27489-61-8) + N-benzoyl-2',3'-di-O-benzoylcytidine 5'-β-cyanoethylphosphate (74316-30-6) → β-cyanoethyl ester of N-benzoyl-2',3'-di-O-benzoylcytidine 5'--1-phosphate (74307-76-9,74345-85-0)

Guidance literature:

With 1-benzenesulfonyl-1H-tetrazole; In pyridine; for 24h; Ambient temperature;

Reference yield:

p-hydroxycyclohexylamine (6850-65-3) → β-cyanoethyl ester of N-benzoyl-2',3'-di-O-benzoylcytidine 5'--1-phosphate (74307-76-9,74345-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 48 h / Ambient temperature

2: 1.) 2,4,6-triisopropylbenzene sulfonyl chloride (TPS); 2.) H₂O / 1.) 40 h; 2.) r.t., 2.5 h

With 2,4,6-triisopropylphenylsulfonyl chloride; water; In methanol;

Reference yield:

p-hydroxycyclohexylamine (6850-65-3) → β-cyanoethyl ester of N-benzoyl-2',3'-di-O-benzoylcytidine 5'--1-phosphate (74307-76-9,74345-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 48 h / Ambient temperature

2: 28.7 percent / benzenesulfonyltetrazole / pyridine / 24 h / Ambient temperature

With 1-benzenesulfonyl-1H-tetrazole; In pyridine; methanol;

upstream raw materials:

N-((trans)-4-hydroxycyclohexyl)acetamide

N-benzoyl-2',3'-di-O-benzoylcytidine 5'-β-cyanoethylphosphate

p-hydroxycyclohexylamine

N,2',3'-O-tribenzoylcytidine

Downstream raw materials:

cytidine 5'--1-phosphate

cytidine 5'trans-4(acetyamidocyclohexyl)-1-phosphate

Refernces