C₆₃H₆₀Cl₂N₈O₁₇P₂

Base Information

• Chemical Name: C₆₃H₆₀Cl₂N₈O₁₇P₂
• CAS No.: 85240-12-6
• Molecular Formula: C₆₃H₆₀Cl₂N₈O₁₇P₂
• Molecular Weight: 1334.07
• Mol file: 85240-12-6.mol

Synonyms:

Chemical Property of C₆₃H₆₀Cl₂N₈O₁₇P₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₃H₆₀Cl₂N₈O₁₇P₂

There total 20 articles about C₆₃H₆₀Cl₂N₈O₁₇P₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) (72351-28-1) → C63H60Cl2N8O17P2 (85240-12-6)

Guidance literature:

Multi-step reaction with 5 steps

1: dioxane / 2 h / 20 °C

2: 1-methylimidazole / dioxane / 3 h / 20 °C

3: benzenesulfonic acid / CHCl₃; methanol / 0.25 h / 0 °C

4: 71 percent / 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole / pyridine / 3 h / 20 °C

5: triethylamine / pyridine / 3 h / 20 °C

With 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole; triethylamine; benzenesulfonic acid; 1-methyl-1H-imidazole; In 1,4-dioxane; pyridine; methanol; chloroform;

DOI:10.1002/hlca.19820650803

Reference yield:

2-chlorophenyl dichlorophosphate (15074-54-1) → C63H60Cl2N8O17P2 (85240-12-6)

Guidance literature:

Multi-step reaction with 6 steps

1: triethylamine / dioxane / 1 h / 20 °C

2: dioxane / 2 h / 20 °C

3: 1-methylimidazole / dioxane / 3 h / 20 °C

4: triethylamine / pyridine / 3 h / 20 °C

5: 71 percent / 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole / pyridine / 3.5 h / 20 °C

6: triethylamine / pyridine / 3 h / 20 °C

With 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole; triethylamine; 1-methyl-1H-imidazole; In 1,4-dioxane; pyridine;

DOI:10.1002/hlca.19820650803

Reference yield:

C66H63Cl2N9O17P2 (78111-51-0) → C63H60Cl2N8O17P2 (85240-12-6)

Guidance literature:

With triethylamine; In pyridine; at 20 ℃; for 3h;

DOI:10.1002/hlca.19820650803

upstream raw materials:

C₆₆H₆₃Cl₂N₉O₁₇P₂

2-chlorophenyl dichlorophosphate

N-isobutyryl-2'-deoxyguanosine

4,4'-dimethoxytrityl chloride

Refernces

• 1、 Denny, William A.,Leupin, Werner,Kearns, David R.. "Simplified Liquid-Phase Preparation of Four Decadeoxyribonucleotides and their Preliminary Spectroscopic Characterization". . p. 2372 - 2393. Retrieved 2007/10/02.