Cyclohexylsulfamoyl Chloride

Base Information

• Chemical Name: Cyclohexylsulfamoyl Chloride
• CAS No.: 10314-35-9
• Molecular Formula: C6H12ClNO2S
• Molecular Weight: 197.686
• Hs Code.: 2935909099
• DSSTox Substance ID: DTXSID60512831
• Wikidata: Q82372244
• Mol file: 10314-35-9.mol

Synonyms:Cyclohexylsulfamoyl Chloride;10314-35-9;N-cyclohexylsulfamoyl chloride;cyclohexylsulfamoylchloride;MFCD11109158;cyclohexylaminosulfonyl chloride;Sulfamoyl chloride, cyclohexyl-;cyclohexylsulfamyl chloride;cyclohexylamino sulfonylchloride;cyclohexylsulfamic acid chloride;SCHEMBL3273144;DTXSID60512831;FGZSEUXOFDMNEL-UHFFFAOYSA-N;AKOS006308434;NS-01987;SY018713;CS-0209850;A896609

Chemical Property of Cyclohexylsulfamoyl Chloride

Chemical Property:

• Boiling Point: 105 °C(Press: 0.15 Torr)
• PKA: 7.34±0.20(Predicted)
• PSA: 54.55000
• Density: 1.32±0.1 g/cm3(Predicted)
• LogP: 2.86400
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 197.0277275
• Heavy Atom Count: 11
• Complexity: 203

Purity/Quality:

98%,99%, ^*data from raw suppliers

CyclohexylsulfamoylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)NS(=O)(=O)Cl

Technology Process of Cyclohexylsulfamoyl Chloride

There total 4 articles about Cyclohexylsulfamoyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

cyclohexylsulfamic acid (100-88-9) → cyclohexylsulfamoyl chloride (10314-35-9)

Guidance literature:

With phosphorus pentachloride; In benzene;

Reference yield:

sodium cyclamate (139-05-9) → cyclohexylsulfamoyl chloride (10314-35-9)

Guidance literature:

With phosphorus pentachloride; In benzene; for 2h; Heating;

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) → cyclohexylsulfamoyl chloride (10314-35-9)

Guidance literature:

Multistep reaction; (i) HCl, MeCN, (ii) SO₂Cl₂, SbCl₅;

upstream raw materials:

cyclohexylsulfamic acid

cyclohexylamine

sodium cyclamate

Downstream raw materials:

N-Cyclohexyl-N'-ethylschwefelsaeurediamid

C₉H₁₉N₃O₂S₂

C₁₀H₂₁N₃O₂S₂

C₂₂H₂₈N₄O₄S

Refernces

• 1、 Benson,Spillane. "Structure activity studies on sulfamate sweeteners". . p. 869 - 872. Retrieved 1976.
• 2、 Dow, Robert L.,Paight, Ernest S.,Schneider, Steven R.,Hadcock, John R.,Hargrove, Diane M.,Martin, Kelly A.,Maurer, Tristan S.,Nardone, Nancy A.,Tess, David A.,DaSilva-Jardine, Paul. "Potent and selective, sulfamide-based human β3-adrenergic receptor agonists". . p. 3235 - 3240. Retrieved 2007/10/03.
• 3、 Davern, Peter,Sheehy, James,Smyth, Timothy. "Chemical and Biological Reactivity of Sulfamidopenicillins". . p. 381 - 388. Retrieved 2007/10/02.