1,3-DIACETOXYACETONE

Base Information

• Chemical Name: 1,3-DIACETOXYACETONE
• CAS No.: 6946-10-7
• Molecular Formula: C7H10 O5
• Molecular Weight: 174.153
• Hs Code.: 2915390090
• Mol file: 6946-10-7.mol

Synonyms:2-Propanone,1,3-dihydroxy-, diacetate (6CI,8CI); 1,3-Di(acetoxy)-2-oxopropane;1,3-Diacetoxyacetone; 1,3-Diacetoxypropan-2-one; 1,3-Dihydroxy-2-propanonediacetate; 1,3-Dihydroxyacetone diacetate; 2-Oxo-1,3-diacetoxypropane; NSC403750; NSC 524606; NSC 53175

Chemical Property of 1,3-DIACETOXYACETONE

Chemical Property:

• Vapor Pressure: 0.0334mmHg at 25°C
• Melting Point: 48.0 to 52.0 °C
• Boiling Point: 243℃
• Flash Point: 101℃
• PSA: 69.67000
• Density: 1.175
• LogP: -0.31830
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,3-Diacetoxyacetone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-DIACETOXYACETONE

There total 1 articles about 1,3-DIACETOXYACETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid (64-19-7,77671-22-8) + Glyceraldehyde (56-82-6,367-47-5,26793-98-6) → peracetylated tagatose + 1,3,4,5,6-penta-O-acetyl-keto-D-fructose (6341-07-7) + peracetylated sorbose (214490-56-9) + 1,3-diacetoxyacetone (6946-10-7)

Guidance literature:

Glyceraldehyde; With zinc(II) bis(L-proline); In water; at 20 ℃; for 168h;

acetic acid; With pyridine; dmap; for 24h; Further byproducts given. Title compound not separated from byproducts;

DOI:10.1039/b501512j

Reference yield: 93.0%

1,3-diacetoxyacetone (6946-10-7) + Methyltriphenylphosphonium bromide (1779-49-3) → 1,3-diacetoxy-2-methylenepropane (3775-29-9)

Guidance literature:

Methyltriphenylphosphonium bromide; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h;

1,3-diacetoxyacetone; In tetrahydrofuran; at -78 ℃; for 3h;

DOI:10.1021/ol401922r

Reference yield: 93.0%

1,3-diacetoxyacetone (6946-10-7) + [(Z)-4-chloro-6-{(2R,4R,5S)-4-[(3,4-dimethoxybenzyl)oxy]-5-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]tetrahydrofuran-2-yl}hex-3-en-1-yl]triphenylphosphonium iodide → 2-[(Z)-4-chloro-6-{(2R,4R,5S)-4-[(3,4-dimethoxybenzyl)oxy]-5-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]tetrahydrofuran-2-yl}hex-3-en-1-ylidene]propane-1,3-diyl diacetate

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 4h; Inert atmosphere; Molecular sieve;

DOI:10.1055/s-0036-1588169

upstream raw materials:

acetic acid

Glyceraldehyde

Downstream raw materials:

acetoxy-pyruvaldehyde bis-(2,4-dinitro-phenylhydrazone)

4-(2-acetoxy-1-acetoxymethyl-ethylidene)-2-phenyl-4H-oxazol-5-one

4-(2-acetoxy-1-acetoxymethyl-ethylidene)-2-phenyl-4H-thiazol-5-one

(2-oxo-5-phenyl-1,3-dioxolan-4-yl)methyl acetate

Refernces