1-(3-cyano-benzyl)-4-methyl-1H-indole-2-carboxylic acid (4-dimethylamino)-benzyl amide

Base Information

• Chemical Name: 1-(3-cyano-benzyl)-4-methyl-1H-indole-2-carboxylic acid (4-dimethylamino)-benzyl amide
• CAS No.: 229953-80-4
• Molecular Formula: C₂₇H₂₆N₄O
• Molecular Weight: 422.53
• Mol file: 229953-80-4.mol

Synonyms:

Chemical Property of 1-(3-cyano-benzyl)-4-methyl-1H-indole-2-carboxylic acid (4-dimethylamino)-benzyl amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-cyano-benzyl)-4-methyl-1H-indole-2-carboxylic acid (4-dimethylamino)-benzyl amide

There total 3 articles about 1-(3-cyano-benzyl)-4-methyl-1H-indole-2-carboxylic acid (4-dimethylamino)-benzyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-methyl-1H-indole-2-carboxylic acid (18474-57-2) + (4-aminomethylphenyl)dimethylamine (19293-58-4) → 1-(3-cyano-benzyl)-4-methyl-1H-indole-2-carboxylic acid (4-dimethylamino)-benzyl amide (229953-80-4)

Guidance literature:

With diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine;

Reference yield:

1-(3-cyano-benzyl)-4-methyl-1H-indole-2-carboxylic acid ethyl ester → 1-(3-cyano-benzyl)-4-methyl-1H-indole-2-carboxylic acid (4-dimethylamino)-benzyl amide (229953-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide

2: diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine

With sodium hydroxide; diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine;

Reference yield:

4-methyl-1H-indole-2-carboxylic acid ethyl ester (16732-80-2) → 1-(3-cyano-benzyl)-4-methyl-1H-indole-2-carboxylic acid (4-dimethylamino)-benzyl amide (229953-80-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride

2: sodium hydroxide

3: diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine

With sodium hydroxide; diphenylphosphoranyl azide; sodium hydride; N-ethyl-N,N-diisopropylamine;

upstream raw materials:

4-methyl-1H-indole-2-carboxylic acid

(4-aminomethylphenyl)dimethylamine

4-methyl-1H-indole-2-carboxylic acid ethyl ester

Refernces