fusidine

Base Information

• Chemical Name: fusidine
• CAS No.: 3482-49-3
• Molecular Formula: C₃₁H₄₈O₆
• Molecular Weight: 516.719
• Mol file: 3482-49-3.mol

Synonyms:

Chemical Property of fusidine

Chemical Property:

• Melting Point: >125°C (dec.)

Purity/Quality:

99% ^*data from raw suppliers

LumifusidicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Lumifusidic Acid is a derivative of Fusidic Acid (F855500), a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.

Technology Process of fusidine

There total 6 articles about fusidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

fusidic acid sodium salt → fusidine (3482-49-3,4680-36-8,6990-06-3,19030-42-3,107380-53-0)

Guidance literature:

With acetic acid; In water;

DOI:10.1016/j.phytol.2018.04.003

Reference yield:

fusidic acid hemihydrate → fusidine (3482-49-3,4680-36-8,6990-06-3,19030-42-3,107380-53-0)

Guidance literature:

In acetonitrile; at 20 - 25 ℃; Product distribution / selectivity;

Reference yield:

→ fusidine (3482-49-3,4680-36-8,6990-06-3,19030-42-3,107380-53-0)

Guidance literature:

aus Mevalonsaeure enzymatisch (Mechanismus d.B.);

DOI:10.1039/C39720001191

upstream raw materials:

fusidine

Downstream raw materials:

1,2,5-trimethylnaphthalene

1,8-dimethylphenanthrene

3,11-diketofusidic acid

(1S,2R,4aS,4bS,5R,6aR,9aS,10aS,10bS,12aS)-2,5-dihydroxy-1,4a,10a,10b-tetramethyl-7-(4-methylpent-3-en-1-yl)-1,2,3,4,4a,4b,5,6,6a,9a,10,10a,10b,11,12,12a-hexadecahydro-8H-naphtho[2′,1′:4,5]indeno[2,1-b]-furan-8-one

Refernces

• 1、 -. "PREPARATION OF A CRYSTALLINE ANTIBIOTIC SUBSTANCE". Page/Page column 33-34. . Retrieved 2008/06/13.
• 2、 Godtfredsen,Von Daehne,Tybring,Vangedal. "Fusidic acid derivatives. I. Relationship between structure and antibacterial activity.". . p. 15 - 22. Retrieved 2007/10/13.